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Here we provide new experimental results on multicomponent reactions of amines with aldehydes and H(2)S in the directed synthesis of functionally-substituted 1,3-thiazetidines, 1,3,5-dithiazinanes, 1,3,5-thiadiazinanes, 1,5-dithia-3,7-diazacyclooctanes, and thioaza macrocycles. X-ray analysis gave insight into the structure of the synthesized compounds. New kinds of multicomponent reactions (MCR) have been discovered and characterized.

2 S at 70 °C affords predominantly the corresponding N (1,3,5 dithiazinan 5 yl)amides, whereas this reaction at 0--50 °C gives a mixture of the latter compounds with 3 acyl 1,3,4 thiadiazolidines. N (1,3,5 Dithiazinan 5 yl) amides were selectively synthesized by the reaction of carboxylic acid hydrazides with formal dehyde and H 2 S in the presence of BuONa in BuOH.

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