Association of blood pressure response during exercise of cardiometabolic risk factors (CMRF) is demonstrated in adults. The objective was to determine predictors of raised exercise blood pressure (BP) response during aerobic exercise in obese adolescents.The maximal treadmill test using the Bruce protocol was performed in 82 normotensive obese adolescents (12–17 y.o., 43 boys). Adolescents were divided into 2 groups: group 1 (n = 68) – children with normal BP response to exercise; group 2 (n = 14) – adolescents who had excessive increase in systolic BP (SBP) during exercise. We used logistic regression analysis to examine the associations between cardiometabolic risk factors (CMRF) and SBP response during exercise with adjustment for baseline SBP, sex, age and duration of exercise test period.We have found exaggerated BP response to exercise in 17.1 % of patients. In adolescents of group 2 baseline SBP was higher than in group 1 (p = 0.01). Glucose level and lipid metabolism disturbances, SDS Z-score, baseline SBP levels only by 24.8 % explained the formation of the hyperreactive SBP response to exercise (χ2 = 13.2; р = 0.068). Only baseline SBP was an independent predictor for exaggerated BP response (p = 0.025) and age was a significant trend towards influence (p = 0.054).Exaggerated BP response to exercise in normotensive obese adolescents is more common for older adolescents who have baseline SBP levels in the range of elevated normal values. Knowing CMRF as well as the degree of excess weight has no effect on excessive BP rise during exercise.

The problem of overweight and obesity is one of the most urgent health issues in the world. 13% of girls and 21% of boys aged 11 suffer from overweight in the Russian Federation.The main causes of pubertal obesity are endocrine pathology, lifestyle and genetic disorders including mutation and polymorphisms of different metabolic pathways. Leptin produced in adipose tissue participates in reproduction regula-tion, glucose homeostasis, bone formation, etc. These effects are provided by leptin receptors coding LEPR gene. Q223R (rs1137101) polymorphism is associated with an increased serum level of leptin and overweight. There is no exact information about association between this polymorphism and obesity of adolescent females. The objective was to reveal LEPR Q223R polymorphism association between overweight and obesity in adolescent females.123 Caucasian adolescent females were involved in this study. All samples could be separated into two groups: the girls with normal weight (SDS BMI ±1.0; controlgroup), girls with overweight and obesity (SDS BMI≥ +1.0–2.0; studied group). Anthropometric measurements (weight, height, waist and hip circumference, body fat percentage) were taken, and genotyping was performed using polymerase chain reaction with electrophoresis detection.G-allele frequency was 43.1% in control and 40% in the clinical group. We found no significant differences of the prev-alence of polymorphism Q223Rbetween the studied groups (р=0,862). Furthermore, there was no association between the carriage of AG and GG with weight, BMI, body fat percentage, waist and hip circumference in both groups (р> 0.05).We have not found any association between LEPR Q223R and overweight and obesity in adolescent females.

The article is devoted to one of actual problems of gastroenterology – study of microbiocenosis of gastrointestinal tract in functional disorders. Functional gastrointestinal disorders (FGID) or minimal dysfunctions of digestion are frequent in the first months of child’s life and provoke anxiety both in parents and in pediatricians. Aim: to explore the microbial landscape and the associative structure of the microbiota of the large intestine in children with functional disorders of the gastrointestinal tract.Subjects and methods: Intestinal microbiota composition of 225 children with functional gastrointestinal disorders and 100 healthy children was studied using bacteriological method.Results. The 88.4 % frequency of detection of intestinal eubiosis disorders is discussed. Information is provided on the species composition of the major opportunistic organisms that inhabit this biotope. According to the results, decrease of bifidobacteria amount in structure of large intestine microbiota increases rate of detection of opportunistic micro-organisms – predominantly, Klebsiella genus bacteria and Staphylococcus aureus. The intestinal microbial community is dominated by multicomponent transient association. The frequency of detection of pathogenic Staphylococcus in children under one year is discussed in detail.Conclusions. A distinctive feature of the intestinal biocenosis microecological status is significantly greater spread of enterococci than in healthy children, which can be a risk for the emergence of strains with the presence of a number of pathogenecity factors that cause infectious processes.

46 Клиническая медицина УДК 159.91:616.12 1 ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека», Иркутск, Россия 1 ФГБОУ ВО «Иркутский государственный университет», Иркутск, Россия Исследованы особенности межполушарной асимметрии у мальчиков и девочек с артериальной гипертензией. Суммарные показатели сенсомоторной асимметрии свидетельствовали о значительных отклонениях в формировании межполушарной функциональной асимметрии только в группах мальчиков, тогда как у девочек основной группы и группы сравнения различия по показателям асимметрии были умеренными и не достигали степени статистической значимости. Это связывается с особенностями адаптации мальчиков с артериальной гипертензией к изменениям нормального функционирования сердечно-сосудистой системы. Ключевые слова: функциональная межполушарная асимметрия, артериальная гипертензия, дети и подростки, мальчики и девочкиPeculiarities of hemispheric asymmetry in 59 boys and 39 girls with arterial hypertension (mean age -15.1 ± 1.5) were studied. The comparison group of healthy children included 60 boys and 37 girls (mean age -14. 9 ± 1.3). The total indicators of sensorimotor asymmetry showed significant deviations in formation of functional hemispheric asymmetry only in the group of boys. At the same time, differences of the asymmetry indicators between main group of girls and the one of comparison were quite moderate and did not reach the level of statistical significance. It is associated with adaptation features of the boys with hypertension to changes of normal functioning of cardiovascular system.