rhITF oral spray formulation was safe and effective when used for the reduction of chemotherapy-associated OM in patients with colorectal cancer. Patients exhibited high compliance in dosing administration. Future clinical study is planned to develop this drug for use in OM management in patients with cancer.

The article is devoted to the problem of voice rehabilitation of patients after laryngectomy. Modern possibilities of repairing laryngeal vocal function, methods for extending the lifetime of voice prostheses are considered. The author’s method of prevention of infection of vocal prostheses using the antimicrobial photodynamic therapy (PDT) with chlorin-type photosensitizer Radagel is presented. Performing antimicrobial PDT of vocal prostheses increased the average operating time to 11.9 months compared to the control group (6.8 months), where a monthly dose of 150 mg of fluconazole was used for prevention. The method developed by the authors makes it possible to significantly extend the lifetime of vocal prostheses, is devoid of adverse events, is well tolerated by patients.

The authors consider the possibilities of pain management during photodynamic therapy (PDT) of visible tumors based on the observation of 102 patients. Of the total number of patients, 62 had verified basal cell skin cancer, 10 people - squamous cell skin cancer, another 10 - oral and oropharynx mucosa cancer, 8 - oral leukoplakia and dysplasia, in 6 - lower lip cancer, in 4 - breast cancer, in 2 - other localizations of neoplasms. In 15 patients, nonsteroidal anti-inflammatory drugs (NSAID) were used as pain management, in 69 - a combination of NSAID with tramadol, in 14 - nerve block anesthesia, in 4 - PDT was performed under general anesthesia. The intensity of pain syndrome during laser irradiation of the tumor was assessed on the verbal rating scale (VRS). The absence of pain was recorded in 9% of cases. Mild pain was noted by 58% of patients, moderate pain - 20%, severe pain - 10%, very severe pain was noted by 3% of patients.The degree of expression of pain syndrome during PDT depends on the incidence of a lesion, histological form of tumor, and method of anesthesia. NSAID alone, or in combination with an opioid analgesic, allows effective control of pain syndrome in PDT of basal cell skin cancer in 89%, in PDT of squamous cell skin cancer in 66% of observations. Nerve block anesthesia allows stoping pain syndrome during PDT of oropharyngeal tumors.

Background: Cancer patients suffer from many complications caused by both the disease itself and the side effects of anticancer treatment. Many symptoms go unnoticed by doctors because of the patient's remote location, significant interruptions between face-to-face visits to the doctor and differences in the individual course of the disease.In a pandemic caused by Covid 19, cancer patients are at great risk. The practical impossibility of patient's visit to a doctor, conduct clinical trials determines the highest risk for this group of patients. Thus the relevance of remote support for these patients in isolation increases many times. Objective: The goal was to create and implement in a pilot project a digital service (ONCONET system) for remote monitoring of cancer patients outside the hospital as well as adaptation to COVID 19 pandemic. Methods: The developed platform is a cloud service hosted in a data processing center which provides healthcare organizations with a ready-made service. The system is based on specialized questionnaires developed by oncologists for remote assessment of the patient's condition. The important component of the system are content libraries for patients and doctors, information and reference materials as the collection of video-schools from leading experts of nosology, rules of life, nutrition, rehabilitation and care. Results: To evaluate the effectiveness of the ONCONET system, 2 groups of patients were formed: ONCONET group -206 patients and retrospective control group -209 patients. Statistical analysis revealed significant differences between groups as a whole, as well as between individual factors of complications. Conclusion: The study demonstrates the usefulness and high medical efficiency of the ONCONET system for remote monitoring of cancer patients, especially against the background of a pandemic and the necessary self-isolation of cancer patients.

Objectives: To study the development of professional deformity in oncological hospital doctors under the influence of professional activity factors. To consider the issues of professional adaptation of medical workers from the perspective of their development of psychoemotional burnout in combination with the problem of physiological and psychophysiological aspects of professional maladaptation. Methods: The analysis of the features of maladaptive reactions of the cardiovascular system of oncological hospital doctors that occur in the course of their professional activities is based on the analysis of changes in three groups of indicators of adaptive response of the cardiovascular system of oncologists, characteristics of blood pressure, heart activity indicators, and the state of peripheral vascular tone. Calculations of the values of psychophysiological indices that integrally characterize the functional state of their body are made. All of the doctors participating in the survey gave informed consent on the acquisition and processing of data. Results: It was found that a significant number (75%) of the tested oncologists have reduced adaptive capabilities of the circulatory system. A significant number of individuals with low stroke (40%) and minute blood volume (30%) were identified. In most cases (up to 68.4%) the examined specialists of the oncological hospital are in a state of impaired professional adaptation according to psychophysiological criteria. Conclusions: It is proposed to use the physiological and psychophysiological indicators used in the study as psychophysiological correlates of the formation and development of professional maladaptation in doctors of different specialties, as well as to control the dynamics of their condition during medical and social rehabilitation of medical institutions.