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Relevance. Patients with diabetes are prone to complications which negatively affect their quality of life. In such patients, several comorbidities may develop. One of the complications of diabetes mellitus is an impaired wound healing. Oral wound healing associated with the constant chronic trauma by sharp edges of teeth and prostheses is not an exception. Such wounds are characterized by a long, persistent, sluggish process of restoring the integrity of the oral mucosa epithelium.Materials and methods. In this paper, a comparative analysis of the effectiveness of wound treatment was carried out in 52 patients with diabetes mellitus. All patients were randomized into two equal groups. In the first group of patients, wounds were treated with traditional methods of pharmacotherapy, while in the second group, the oral mucosa was exposed to ozone and ozonated oil was applied. The patients were monitored and followed up for 14 days and as the reparative function was restored. The area and depth of the wound, the nature and amount of exudate, destruction, the edges of the wound and the surrounding connective tissue were taken into account.Results. The positive wound healing process was noted in both groups during the follow-up period. However, the inclusion of the ozone therapy in the treatment protocol favored faster restoration of the epithelium integrity.Conclusion. The present data will help dentists monitor and treat the wound process, which in turn will prevent malignancy as well as improve the prognosis for patients with diabetes.

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Relevance. The high necessity in orthodontic treatment among young patients and the use of fixed orthodontic appliances for the treatment of dental pathology are the factors that initiate inflammatory periodontal processes. Timely diagnosis and optimal preventive and treatment procedures can prevent or stop the inflammatory periodontal complications which could have developed during the orthodontic treatment. One of the effective methods for the prevention and treatment of inflammatory periodontal diseases is the use of targeted antimicrobial agents based on medicinal plants that have specific antimicrobial activity against periodontal pathogens. Purpose – to study the effectiveness of the dental gel with barberry extract for the treatment of plaque-induced gingivitis in orthodontic patients during the active phase of the treatment with fixed appliances.Materials and methods. The study included 60 patients (35 women and 25 men) aged 18 to 35 years who had presented for the orthodontic care. The patients undergoing orthodontic treatment with fixed appliances were randomly divided into two groups. In group I, the patients were prescribed applications of a dental gel with barberry extract; in group II, this medication was not prescribed. The clinical condition of the periodontium was assessed with periodontal indices PMA, SBI and OHI-S. The immune status was evaluated by the level of secretory IgA, interleukins (IL-1β and IL-4) and tumor necrosis factor-α (TNF-α). The patients were followed up during 1 month of treatment. The results were statistically processed with Statsoft Statistica 8.0 and Graph Pad Prism 5.0.Results. In group II, the production of immunoglobulin IgA, pro- and anti-inflammatory cytokines was impaired after a month of treatment, associated with a significant deterioration in the oral hygiene status and an increase in PMA (by 3 times), SBI (by 5.3 times) indices. In group II, the oral fluid concentrations of IL-1β, IL-4 and TNF-α significantly differed from those in group I as of the 7th day of the observation period and indicated suppression of the mucosal immunity. Clinical and immune parameters of the group I patients improved and were comparable with the control by the end of the observation month.Conclusions. Patients with dental abnormalities are at risk of developing inflammatory periodontal diseases. The results of the immunological tests, performed during the treatment with the use of a dental gel with barberry extract, demonstrated the recovery of the local immunity, as evidenced by the elevation of secretory immunoglobulin A in saliva and improvement of cytokine profile parameters.