The main directions of research in the field of nanosized carrier systems for targeted delivery of drugs are reviewed. The fields of research and the results from characterization of the pharmacological properties of nanosized forms of drugs, including nanospheres, liposomes, dendrimers, fullerenes, nanocapsules, and nanocrystalline forms of drugs are considered. Prospects of the search for new forms of drugs based on achievements in nanobiotechnology are considered with a view to the reduction of side effects and improvement of the bioavailability of drugs.

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A method for determining riboflavin in complex medicinal forms is developed and makes use of an HPLC with mass-spectrometric detection and electrospray ionization (HPLC/MS-API-ES). Conditions of sample preparation for the analysis of riboflavin with a sensitivity of 1´10 -5 mg/mL are optimized. The proposed technique has been checked using the "introduced-found" approach. The technique is successfully used for the analysis of commercial vitamin-mineral complexes.