Marqueurs cliniques des troubles immunitaires dans la pathogenèse de la coli entérite Introduction. La coli entérite est l'une des causes les plus courantes de diarrhée dans les pays développés et est généralement causée par des souches pathogènes d'Escherichia coli. Objectif: étudier le rôle de la réponse réactive des granulocytes neutrophiles polymorphonucléaires (GN) du sang périphérique dans les mécanismes de réponse inflammatoire systémique de l'entérocolite aiguë d'Escherichia (AEC) en fonction du polymorphisme des gènes de la protéine de choc thermique (HSP) de la famille 70-2 (HSP70-2, 1267A®G) et l'interleukine 10 (IL-10, C-592A). Méthodes. Le polymorphisme des gènes a été analysé par la méthode basée sur la PCR chez 95 patients avec AEC et 30 individus en bonne santé. Les marqueurs cliniques des troubles immunitaires ont été évalués à l'aide d'indices hématologiques, basés sur une analyse ABSTRACT Background. Escherichia coli enteritis is one of the most common causes of diarrhea in developed countries and is caused usually by pathogenic strains of Escherichia coli. Objectives. To investigate the role of reactive response of polymorphonuclear neutrophilic granulocytes (NG) of peripheral blood in the systemic inflammatory response mechanisms of acute Escherichia enterocolitis (AEC), depending on genes polymorphism of heat shock proteins (HSP) family 70-2 (HSP70-2, 1267A®G) and interleukin 10 (IL-10, C-592A). Material and methods. The genes polymorphism was analysed by PCR based method in 95 patients with AEC and 30 healthy individuals. Clinical markers of immune disorders were evaluated after hematological indices, based upon an extended general clinical blood analysis, using verified formulas. Results. The endogenous intoxication severity did not depend reliably on genotypes of IL-10 gene (rs1800872), however it was significantly 23.68%
Резюме. В експерименті на білих щурах пр одемонстровано можливість дискретного моделювання рі-зних форм (набрякова, некротична) гострого експериментального панкреатиту, шляхом використання локального кріовпливу на тканини підшлункової залози власним способом. Для кріовпливу викорис-таний пристрій, створений на базі термоелектричного модуля Пельтьє. Виконані гістологічні дослі-дження засвідчили, що набрякова форма панкреатиту розвивається, якщо локальний кріовплив на під-шлункову залозу запропонованим способом триває 10-20 секунд, а некротична -понад 25 секунд. Ключові слова: експериментальний панкреатит, кріовплив, гістологія, модуль Пельтьє.
The results of the study of the structural changes of pancreas, lipid metabolism and systemic inflammatory response considering the etiological factor and gender of patients with acute pancreatitis and exacerbation of chronic pancreatitis are presented in the article. It was estimated, that acute biliary pancreatitis is accompanied by a stronger systemic inflammatory response according to the level of C-reactive protein (p=0.027) and significant dyslipidemic disorders. The structural changes of the pancreas during acute alcoholic pancreatitis are characterized by a moderate inflammatory reaction of the parenchyma, parapancreatic hydrophily and the appearance of small cysts. Biliary acute pancreatitis is associated with a greater frequency of acute inflammatory changes of the pancreas structure: the decrease in echogenicity and its heterogeneity. Thus, there are differences in the degree of severity and structural changes of pancreas, depending on etiological factors, within the context of dyslipidemic disorders and systemic inflammatory response of acute pancreatitis or exacerbation of chronic pancreatitis.
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