Ten secondary metabolites including flavonoids (1-8), caffeic (9) and chlorogenic (10) acids were structurally identified from the extract of Sakhalin bilberry Vaccinium smallii leaves and studied in vitro as potential cancer-preventive agents. The results showed that compounds 1-10 inhibited EGF-induced neoplastic transformation of mouse JB6 Cl 41 P+ cells in soft agar with an inhibition concentration (INCC50) of 20-80 µm. Moreover, all these natural products were non-toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm.

A new procedure has been developed for the quantitative determination of polyphenolic compounds in strawberry (Fragaria orientalis ) leaves by means of spectrophotometry in the visible spectral range. The procedure is based on the oxidation of phenolic compounds by the Folin -Denis reagent. The relative error of determination does not exceed 3.8% at a confidence probability of P = 95%. Optimum conditions for the Folin -Denis reaction have been established. 97 0091-150X/07/4102-0097

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