The aim of the investigation was to study the effect of 2-ethyl-6-methyl-3-hydroxypyridine malate (Ethoxidol) on the concentration of oxidative stress metabolites in patients with chronic heart failure (CHF) and hypertension. Materials and Methods. 126 patients with FC I-III CHF have been examined. In addition to their individual therapy these patients received intravenous infusions of Ethoxidol. Blood content of 2,3-diphosphoglycerate (2,3-DPG), oxygen tension (рО 2), pH, concentration of total peroxides, lactate, and aldosterone were identified. 2,3-DPG levels (g/L erythrocytes) in whole blood samples were determined by an enzyme assay using the reagent kit (Rosh, Germany), values of рО 2 , рСО 2 , рН, lactate in the venous blood were measured using gas analyzer Stat Profil pHOx Ultra (Nova Biomedical, USA). Indices of oxidative stress, i.e. the concentration of plasma total peroxides, were investigated by ELISA using OxyStat kit (Biomedica, Austria). Peripheral venous blood samples were collected from all patients before and 6 days after the daily intravenous Ethoxidol infusion. Results. In patients with FC I, II, III CHF, on day 7 after intravenous Ethoxidol infusion at a dose of 100 mg/day, statistically significant growth (p=0.0002) of PaO 2 level by 15.7, 17.4, and 22.8%, respectively, was noted. In patients with FC I, II, III CHF in the group receiving standard therapy, statistically significant (p=0.002) reduction of 2,3-DPG level by 2.7, 2.4, and 4.0%, respectively, was registered. On day 7 after the infusion of Ethoxidol at a dose of 100 mg/day, its decrease by 5.7, 10.5, and 26.2%, respectively (p<0.0001), was also observed.

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The article focuses on the study of the interaction of digital processes in the “city-region-country” system when assessing the overall level of digital transformation of the Russian economy, since the works devoted to the consideration of the results of the introduction of digital technologies in the country do not analyze the features of territorial digital processes. The research aims at the necessity and possibility to show specific digitalization features of cities and regions in the existing evaluation methods of the Russian economy digital transformation index. The researchers used logical, systematic and comparative analysis methods to analyze the digitalization indicators of the largest Russian cities and regions. The authors analyze the digitalization indicators of the largest Russian cities and regions between 2014– 2018; they define indicators, reflecting regional disproportions of the national economy digitalization; and develop new methods to evaluate digital inequality in the system “city-region-country”. The use of the suggested indicators will improve the existing methods of evaluation of the largest Russian cities digitalization, increase the fairness of digital processes and technologies evaluation for making decisions in the system of state, regional and municipal government.

Пермский государственный национальный исследовательский университет, г. Пермь, РоссияСтатья посвящена исследованию вопросов, связанных с трансформацией менеджмента производственных организации в условиях перехода к Индустрии 4.0. Систематизированы изменения, которые происходят в системе менеджмента производственной организации, участвующей в процессах цифровой трансформации экономики. Определены отличительные особенности цифрового менеджмента в сравнении с традиционным, показано влияние цифровизации функций менеджмента на экономические показатели производственной деятельности организации. Результаты исследования могут быть использованы в практике менеджмента организации для принятия управленческих решений, ориентированных на внедрение цифровых технологий в различные сферы управленческой деятельности.Ключевые слова: ключевые технологии Индустрии 4.0; цифровая трансформация менеджмента; цифровой менеджмент; производственная деятельность; критерии принятия цифровых решений. Цифровизация предприятий -это уже не будущее, а реальность, которая в ближайшее время станет повседневностью. Дитрих Меллер, президент компании «Сименс» в России Управление социально-экономическими системами Александрова Татьяна Васильевна, кандидат экономических наук, доцент, кафедра менеджмента, Пермский государственный национальный исследовательский университет (г. Пермь), atvpsu@yandex.ru Поступила в редакцию 20 июля 2019 г. The article regards researching the issues related to the transformation of management in industrial organizations under conditions of transition to the Industry 4.0. The changes that occur in the production management system of the organization participating in the processes of digital transformation of economy have been systematized. Distinctive features of digital management compared to Управление социально-экономическими системами