An actual direction of scientific research is the problem of diagnosis and treatment of infected wounds. An important place in the general structure of diseases of general surgical profile is occupied by patients with purulent-inflammatory diseases of soft tissues, the frequency of which sometimes reaches indicators of 35–40%. With the development of medical science, ideas about wounds and methods of influencing the purulent-inflammatory process are constantly changing. Based on clinical criteria, three consecutive stages (phases) of the development of the wound process with different pathogenesis can be distinguished: purulent-necrotic (inflammatory) - characterized by the presence of necrotic tissues and purulent content in the wound; stage of granulation (regenerative) – manifested by cleaning the wound from purulent-necrotic sequestration and the formation of granulation tissue in it, which gradually fills the wound cavity; stage of epithelization (healing) – epithelization of the wound surface and formation of a scar. The purpose of the work was the analysis of scientific publications of the Pharmaceutical Journal on the development of the composition and technology of drugs for the treatment of the wound process for 1959–2022. The research materials were scientific publications of the scientific and practical edition of the Pharmaceutical Journal for the past 63 years (1959–2022), which used the methods of systematic and structural-logical analysis. The analysis of the scientific publications of the Pharmaceutical Journal over the past 63 years showed that soft drugs for local use do not lose their relevance for a long time. The appearance of new auxiliary substances, scientific knowledge of the wound process creates the basis for the development of new soft drugs and forms for the treatment of the wound process. The following factors are becoming relevant in drug technology: the basis for soft drugs, the correspondence of the phase of the wound process to soft drugs. The medical and biological requirements for the development of soft drugs are also evolving. The analysis of literature data showed that the use of multicomponent ointments on hydrophilic and emulsion bases, which have dehydrating and wound-healing effects, is technologically justified for the local treatment of the wound process. Soft drugs have a leading role in the local treatment of purulent wounds, as they ensure the achievement of the optimal concentration of active pharmaceutical ingredients in the affected area, ensuring high therapeutic efficiency and prolonged effect. Natural components that are part of wound-healing ointments have a significant breadth of pharmacological action, low toxicity and rarely cause side reactions, unlike synthetic agents.

Wound treatment is complex and differentiated depending on the nature and origin of the wound. Comprehensive treatment of wounds includes both local and general therapeutic measures. Local and general wound healing complement each other and accelerate the achievement of a positive result. Local treatment of wounds is carried out with antiseptics according to the phases of the wound process. Not only medical but also pharmaceutical components are important in the development of a drug for the treatment of wounds, in particular the compliance of a mild drug to the phase of the wound process. The aim of the work was to study the structural and mechanical properties of some model bases for the creation of a mild antimicrobial drug for the treatment of wound processes. The object of the study were model samples of bases made on the basis of polymers (gel) and emulsions of the first kind (oil/water) – cream. In order to create stable emulsions, the surfactant N 1 emulsifier in the maximum amount of 8% and vaseline oil – up to 20% were selected. 10 model samples in the form of gel (samples 1–5) and cream (samples 6–10) were processed and rheological studies were performed. Measurement of rheological parameters of ointment bases was performed using a rotary viscometer Reotest-2 according to the method of the State Pharmacopoeia of Ukraine. Based on the research, it was found that the samples of cream and gel bases belong to the dispersed structured systems, which are characterized by elastic-plastic-viscous properties. Model bases are dispersed systems with coagulation type structure. It is proved that all model samples have a non-Newtonian type of flow. Their fluidity begins after the application of a certain mechanical stress. Lubrication and extrusion of tubes characterize the consumer properties of the samples. It is shown that the flow curves fit within the rheological optimum, which allows us to conclude that the test specimens are satisfactorily lubricated and extruded from tubes. Based on the conducted rheological studies, it was found that the presented model samples can be used as carriers for the creation of pharmaceutical compositions with active pharmaceutical ingredients. The prospects of this study are the study of structural and mechanical parameters of model samples – thixotropy, mechanical stability.