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A computational simulation of water transfer across the blood-brain barrier (BBB) has been carried out. In the developed model, AQP4 plays a kinetically limiting role in water transfer across the BBB. The effects of the AQP4 specific density changes and its polarized distribution have been studied in respect to the volumetric water transfer. It has been demonstrated that AQP4 density and polarization within the glial membranes enveloping the capillary can affect the volumetric flow and the sign of the water flux. The results might be used for elucidation of the pathogenic mechanism of cerebral edema and in development of the ways of pharmacological correction of the cerebral water metabolism disorders.

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The new information, that has become available at present, makes it possible to outline a mechanism of brain water metabolism in the realization of which an important role belongs to AQP4, the main aquaporin of the brain. This aquaporin controls water transfer across the blood-brain barrier and water exchange between brain parenchyma and the cerebrospinal fluid. In the world literature, AQP4 is viewed as a molecular target for the drug action directed at correction of the brain water metabolism disorders in pathologies. The new knowledge made it possible to outline principal approaches to pharmacological correction of cerebral water metabolism disorders and edema.