This study aims to compare the effect of different concentrations of 5 and 10% of M.oleifera (Moringa oleifera L.) and celery (Apium graveolens L.) seeds on glucose levels in diabetic rats. Forty-two adult male albino rats weighing (140-150 g) were divided into seven groups (six rats in each group). The first group was kept as a control (-ve) group, while the other groups were injected with Alloxan (150 mg/kg body weight) to become diabetic rats; one group of them was kept as a control (+ve) while four diabetic groups were treated with different concentrations of M. oleifera and celery. The last group was treated with Glucophage. After 35 days, glucose levels, cholesterol, triglycerides (T.G), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), very lowdensity lipoprotein cholesterol (VLDL-c), kidney functions, and liver functions were evaluated by biochemical tests. The results revealed that both plants decreased glucose levels and improved functions of the kidney and liver by lowering SGPT, SGOT, creatinine, and uric acid. Also, both plants enhanced lipids profile by reduction of serum triglycerides, lowdensity lipoprotein, very low-density lipoprotein, and increased highdensity lipoprotein compared to the positive control group. In conclusion, all biochemical analyses reflect the power of Moringa oleifera and celery seeds as nutraceutical therapeutics for treating diabetes in rats. The best result was recorded at a 10% Moringa oleifera seeds powder concentration.