This research aims to determine the controlling and moderating role of the big five personality factors in the relationship between incivility behavior at workplace and counter productive work behavior (CPWB) applied to staff of nurses at the general and central hospitals in Dakahlia governorate .sample size is 344 respondants and sample type is random stratified , respondant rate is 69.5%. Research results showed that there are positive and negative correlations between some dimensions of incivility behavior in workplace and counter productive work behaviors (CPWB) in hospitals , the results also showed that there is a positive significant effect for the doctors incivility behavior on individual-oriented CPWB.R2 is 9.1% sig. 1% .There is no significant effects for all sources of incivility behavior on organization-oriented CPWB .