Oxidative stress plays an important role in the etiology and pathogenesis of many chronic diseases. Dietary intake of antioxidants can inhibit or delay the oxidation of susceptible cellular substrates so prevent oxidative stress. The present study was designed to investigate potential protective and ameliorate effects of pineapple and kumquat powders against potassium bromate (KBrO3)-induced oxidative stress using experimental rats. Whole kumquat (seedless), kumquat seeds, pineapple flesh and pineapple leaves were analyzed for phenolic compounds. Measurement of potential of cytotoxicity against the liver carcinoma cell line (HEPG2) carried out by SRB assay of the ethanolic extract of whole kumquat seedless, kumquat seeds, whole kumquat, pineapple flesh, pineapple leaves, pineapple (flesh +leaves) and mixture of them.