Adsorption of the new generation antiepileptic drug E Keppra® dry syrup containing 50％ levetiracetam to an automated dividing and packing machine was observed after dispensing by using the machine. We examined drug loss and variation in divided weight after dispensing a pediatric dose of the dry syrup. When 1.4 g of E Keppra® dry syrup 50％ was divided into 14 packs using an automated dividing and packing machine, the drug loss per pack was 10％ -27 ％. The high drug loss was observed during an early stage of packaging the dry syrup. Conversely, drug loss per pack was less than 10％ when 7.0 g of the dry syrup was divided into 14 packs. The variation in divided weight in 1.4 g of the dry syrup was 2.3％, which was larger than the variation in 7.0 g of the dry syrup. The drug loss and variation in divided weight were observed under the following conditions: the dry syrup particles were less than the average particle diameter of 150 μm and the humidity was less than 50％. The drug loss during division was prevented by addition of a vehicle, such as lactose, to the dry syrup. These results indicate that using the machine to divide the E Keppra® dry syrup 50％ into low doses recommended for children gives rise to inaccurate dosing.