Ag ＋ 、Cr 3＋ 、Co 2＋ 、Cu 2＋ 、Pb 2＋ 、Sn 4＋ 、Fe 3＋ 、Zn 2＋ 等金属离子的作用, 结果表明化合物 3a 和 3b 对 Zn 2＋ 具有很好的选 择性识别能力.

衍生物的加成产物用于 1,4,5-三芳基吡唑的合成 郑纯智 a 徐小丹 b 王雅珍 a 赵德建 a 张继振 * ,a (a 江苏理工学院化学与环境工程学院 常州 213001)

A novel and highly efficient synthesis of 3-methyleneisobenzofuran-1(3H)-one and the corresponding derivatives was reported. The new method was characterized with raw material easy to get, low manufacturing cost, mild reaction conditions and high yields. 2-Methylbenzoic acid and their derivatives were used as starting material, methyl 2-((bromotri-phenylphosphoranyl)methyl)benzoate and their derivatives were synthesized through esterification, free-radical bromination with N-bromobutanimide (NBS) and nucleophilic substitution with triphenylphosphine. After Wittig reaction and hydrolysis of carboxylic esters, 2-vinylbenzoic acid and their derivatives were obtained. Then through cyclization reaction with iodine (NBS), 3-iodo(bromo)methylisobenzofuran-1(3H)-one and their derivatives were obtained, which further react by elimination hydrogen halide with 1,8-diazabicyclo[5.4.0]under-7-ene to afford the target compounds. Eleven intermediates were new compounds.

No abstract

An efficient and simple method for the synthesis of chiral benzo[5,6][1,3]oxazino[4,3-c]quinoxaline-dione is reported. 2-Hydroxybenzaldehydes and diamines were utilized as the starting materials, the formed diimines then underwent a reductive-cyclization process with triphosgene to give bis-quinazoline-dione derivatives induced by low-valent titanium reagent. Then through the conversion of functional groups, the bis-quinazoline-dione compounds containing hydroxy group have been obtained from their corresponding compounds containing methoxy group in the presence of BBr 3. In addition, the dihydroxy-bis-quinazoline-dione derivatives were applied on the asymmetric nucleophilic addition of Et2Zn to aldehydes. The reported method is the efficient approach for the synthesis of dihydroxy-bis-quinazoline-dione derivatives.