The purpose of this study was to investigate the effects of shift work and hours of sleep on metabolic syndrome in Korean workers. Methods: This study used the Korean National Health and Nutrition Examination Survey data of 2014. The study included 1,579 Korean workers aged over 20. x 2 test, t-test, and hierarchical multiple logistic regression were used for statistical analysis of data. Results: From the univariate analysis, hours of sleep, regular work, occupational group, sex, age, marital status, education, smoking, and self-rated health were significantly related to metabolic syndrome. After adjusting demographic, occupational, and health-related variables, workers with under 6 hours/day of sleep showed higher risk for metabolic syndrome (AOR: 1.56, 95% CI: 1.01~2.44), and shift work was not significantly related to metabolic syndrome. Male laborers and workers aged 40 or older also showed higher risk for metabolic syndrome. Conclusion: Results of this study suggest that workers with under 6 hours of sleep, male laborers and workers aged 40 or older are the risk groups of metabolic syndrome. Therefore, prevention and management program for metabolic syndrome should be implemented for this population.

Purpose: The purpose of this study was to investigate the influences of job insecurity on job related depression and anxiety in large-and small-sized company employees. Methods: Data of the third Korean Working Condition Survey in 2011 were used. Subjects were 2,050 large-sized company employees and 18,924 small-sized company workers. x 2 test and multiple logistic regression using SAS 9.2 were conducted. Results: Large-and small-sized company employees showed significant differences in terms of demographic, health-related, and job-related characteristics. From the bivariate analysis, gender, income, self-rated health, occupation, working hours per week, job-related stress, workplace violence, and job insecurity were significantly related to job-related depression/anxiety in large-sized company employees. From the multivariate analysis, higher income (AOR: 0.22, 95%CI: 0.07~0.71), better health perception (AOR: 0.05, 95%CL: 0.01~0.18), 40 or more working hours per week (AOR: 0.20, 95%CI: 0.05~0.79) showed lower risk for job-related depression/anxiety. From the bivariate and multivariate analysis, better health perception (AOR: 0.32, 95%CI: 0.20~0.53), higher job-related stress (AOR: 2.57, 95%CI: 1.68~3.93, workplace violence experience (AOR: 4.26; 95%CI: 2.88~6.30), and job insecurity experience (AOR: 1.90, 95%CI: 1.18~3.05) were significantly related to job-related depression/anxiety in small-sized company employees. Conclusion: Results of this study suggest that job insecurity experience was significantly related to job-related depression/anxiety in small-sized company employees but not in large-sized company employees. Therefore, small-sized company workers who have experienced feeling of job insecurity are vulnerable population in terms of job-related depression/anxiety.

Curcumin has diverse anticancer activities that lead to tumor growth inhibition of cancer cells and induction of apoptosis. Curcumin is involved in the regulation of multiple genes via transcription factors including NF-kB, STATs, AP1, and SP. Notch signaling plays critical roles in maintaining the balance between cell proliferation, differentiation and apoptosis, and thereby may contribute to the development of various cancers involving breast cancer. This study was to investigate the effects of curcumin on Notch1 gene expression and to explore the underlying mechanism. Here, we found that curcumin decreased the levels of Notch1 mRNA and protein in MDA-MB-231 human breast cancer cells, along with the downregulation of Sp family genes (Sp1, Sp2, Sp3, and Sp4). The repressive effect of curcumin on Notch1 gene transcription was confirmed by performing Notch1 promoter-driven reporter assay and three Sp-binding sites were identified on Notch1 promoter that may act as curcumin-respose elements. Moreover, treatment with mitramycin A, a specific Sp inhibitor, decreased the levels of Notch1 mRNA and protein in human breast cancer cells. Taken together, our results indicate that Notch1 gene expression is downregulated by curcumin, at least in part, through the suppression of Sp family, which may lead to apoptosis in human breast cancer cells.

The purpose of this study was to evaluate the influence of energy drinks on the erosion of dental enamel and mouse teeth growth. Exposure of enamel surface to energy drinks stimulated the release of the calcium from enamel surface of teeth. And the surface microhardness of enamel decreased after immersion in energy drinks. Enamel demineralization effects under energy drinks were observed by scanning electron microscope. Effect of maternal energy drink intake on tooth morphology of offsprings was analyzed. We concluded that the energy drinks produced a significant erosion of dental enamel.

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