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With continuing demand for the development of new, effective and safe therapies, an investigation was carried out to test the efficacy of an antibacterial agent derived from marine edible seaweed. The methanolic extract of Ecklonia cava from marine edible seaweed evinced potential antibacterial activity against Enterococcus faecalis. Among five solvent-soluble fractions of E. cava methanolic extract, the ethyl acetate soluble extract (EtOAc) exhibited the strongest antibacterial activity, with a MIC value of 128 µg/mL against E. faecalis strains. Furthermore, a synergistic antibacterial effect between an antibiotic and the EtOAc fraction was assessed using fractional inhibitory concentration (FIC) indices. A combination of ciprofloxacin and the EtOAc fraction resulted in a ∑FIC min range of 0.188 and ∑FIC max of 0.508 to 563, suggesting that the ciprofloxacin-EtOAc fraction of E. cava combination resulted in an antibacterial synergy effect against E. faecalis.

발효여과물이 함유된 화장수와 크림을 하루에 3회 피부염병변에 6주간 도포하도록 하였다. 그 결과 SCORAD 지수는 26.9±11.8에서 14.9 ±9.7로 감소(p<0.05), Total IgE(IU/mL)는 641.9±1294.6에서 565.8±1076.8로 감소, Eosinophil의 수 (ug/dL)는 246.7±203.5에서 203.3±130.7로 감소하였다(p<0.05). 피부수분함유량은 36.6±10.0에서 44.0±10.3로 증가 (p<0.01), 경피수분손실량(g/h/m²)은 16.7±5.1에서 15.4±8.7로 감소(p<0.05)하였으며, 피부 pH는 약산성을 유지하였다. 또한 의사 및 환자의 총괄유효성 평가도 증가되었다. Abstact Sixteen moderate atopic dermatitis patients were treated with applying toner and cream using estern medical herbs[Estern medical complex(Radix Glycyrrhizae, Radix Angelicae Dahuricae, Rhizoma Ligustici Chuanxiong, Fructus ponciri Seu Aurantii Immaturus, Radix Rehmanniae Praeparata, Radix Puerariae, Rhizoma Corydalis), Cypress, Green tea, Radix Astragali, Red ginseng, Syrup ferment, Apple ferment filtrate] on the atopic area 2-3 times per day for 6 weeks. After 6 weeks of study, the result was a decrease in SCORAD index(26.9±11.8 to 14.9 ±9.7(p<0.05)), IgE(641.9±1294.6 to 565.8±1076.8), Eosinophil count(246.7±203.5 to 203.3±130.7(p<0.05)) and TEWL(16.7±5.1 to 15.4±8.7(p<0.05)). And skin hydration was increased(36.6±10.0 to 44.0±10.3(p<0.01)) maintaining skin pH level. The patient;s and physician's global assessment also improved. Therefore, estern medical herbs may play a role in treatment of atopic dermatitis.

This study was conducted to identify the relationships among critical thinking disposition, professional self-concept and satisfaction of clinical practice in nursing students. The participants were 212 nursing students in Gyeonggy Province. Data was collected from June 1 to 12, 2015 using self-report questionnaires and analyzed through descriptive statistics, t-test, ANOVA and Pearson correlation coefficient with SPSS/win. 21.0. Critical thinking disposition, professional self-concept and satisfaction of clinical practice averaged 3.61(out of 5), 2.94(4), and 3.54(5), respectively. Significant positive correlations between critical thinking disposition and professional self-concept, satisfaction of clinical practice and professional self-concept were found, Therefore it is necessary to strengthen critical thinking and professional self-concept and improve satisfaction of clinical practice through effective educational program.