No abstract

Abstract:1) The occurrence of dental caries is mainly associated with oral pathogens, especially cariogenic Streptococcus mutans. The aim of this study was to isolate and characterize lactic acid bacterium showing inhibitory activity against cariogenic Streptococcus mutans. As results, an isolate with strong inhibitory activity was obtained from Kimchi and it was identified as Lactobacillus sakei by API and 16S rRNA gene analyses. This strain secreted an inhibitory compound in cell growth medium and the activity of the compound was completely disappeared by proteinase K revealing the fact that the compound is proteinous substance, bacteriocin. Optimal culture condition for bacteriocin production by Lb. sakei K-7 was at pH 7.5 and 37℃ for 18 h. Oral administration of this isolate may give anticariogenic and probiotic effects on hosts. 최근에는 구강내에서효과적인 항충치 작용을 가진 소재를 발굴하기 위해서 1) St. mutans의 증식을 저해하는 작용 [4,5] 2) sucrose로부터 glucan형성에 관여하는 GTase활성 저해 작용 [6,7]

No abstract