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Purpose : The purpose of this study was to compare the clinical outcomes between Seprafilm Ⓡ , Adept Ⓡ groups and control group in colorectal surgery for colorectal cancer.Methods : we retrospectively reviewed the medical records of patients who had undergone a colorectal surgery between February 2008 and January 2010.The patient's demographic and operative outcomes were also evaluated. Of the 454 patients, 114 patients received Seprafilm, 180 patients received Adept Ⓡ and 160 patients in the no additive control group. The age, gender and operative times among three groups were similar.Results : Small bowel obstruction developed in 16 patients in the Adept Ⓡ group (8.9%), in Seprafilm Ⓡ group 5 patients (4.4%), in the control group 11 patients (6.9%) had small intestinal obstruction. The overall incidence was significantly higher in Adept Ⓡ group than in the Seprafilm Ⓡ group and the control group with statistical significance (Adept Ⓡ vs Seprafilm Ⓡ ; P = 0.043 Adept Ⓡ vs Control group, P = 0.002) Conclusion : The application of Seprafilm Ⓡ did not reduce the rate of small bowel obstruction in patients undergoing colorectal surgery for colorectal cancer as compared with no additive group and the application of Adept Ⓡ increased the rate of small bowel obstruction . Thus, it should be considered when using of Adept Ⓡ in colorectal cancer operation as an adhesion reduction agents.