1,25-Dihydroxyvitamin D3 increases striatal GDNF mRNA and protein expression in adult rats

Calcitriol Protection against Dopamine Loss Induced by Intracerebroventricular Administration of 6-Hydroxydopamine

“…Several groups have reported an increase in GDNF levels following calcitriol exposure [17,19,26,40]. In the present study we found an increase in GDNF levels of 37% in the substantia nigra after 8 days of calcitriol injections.…”

“…Cell cultures exposed to calcitriol show enhanced concentrations of GDNF [19], c-glutamyl transpeptidase, glutathione [20][21][22], tyrosine hydroxylase [23], and neurotrophin-3 [24]. Calcitriol can also inhibit production of iNOS [25], and increase levels of GDNF [17,26], in the brain. Taken together, these studies suggest that calcitriol has CNS activity and may provide neuroprotection against various CNS insults.…”

Driving GDNF expression: The green and the red traffic lights

“…These observations suggest that the effect of 1,25-dihydroxyvitamin D 3 on GDNF expression might be cell type dependent. There are also evidences that 1,25-dihydroxyvitamin D 3 increases GDNF levels in vivo (Wang et al, 2000;Sanchez et al, 2002). This neurotrophic effect might contribute to the finding that pretreatment with 1,25-dihydroxyvitamin D 3 protects against 6-OHDA-mediated depletion of dopamine and its metabolites in the substantia nigra, while in vitro it protects primary mesencephalic neurons against 6-OHDA-or H 2 O 2 -induced cell death (Wang et al, 2001b).…”

Effects of 1α,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex

“…Recently it has been shown that 1,25-D 3 also exhibits a strong potential for neuroprotection in several in vitro systems as well as in animal models, including the MCAO model of cerebral ischemia (Wang et al, 2000(Wang et al, , 2001Garcion et al, 2002;Sanchez et al, 2002;Lin et al, 2003;Chen et al, 2003).…”