1‐Isonicotinoyl‐4‐acyl‐thiosemicarbazide

Abstract

1 -Isonicotinoyl-4-acyl-thiosemicarbazide wurden durch Umsetzung von Alkyl-, Alkenyl-, Aryl-, Ar-alkyl-und heterocyclischen Acyl-isothiocyanaten mit lsonicotinsaure-hydrazid gewonnen.

Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region"

“…2-Methoxy-4-nitrophenol was acetylated by treatment with acetic anhydride following the method of Fisher and Hibbert8 to give 4-acetoxy-3-methoxynitrobenzene (82% yield). This compound (8 g, 38 mmol) was hydrogenated in 200 mL of EtOAc containing 200 mg of 10% Pd/C for 4 h. The catalyst was removed by filtration through Celite and washed with 100 mL of EtOAc. A stream of HC1 gas was passed through the solution, causing colorless crystals to precipitate.…”

Direct and Facile Synthesis of Acyl Isothiocyanates from Carboxylic Acids Using Trichloroisocyanuric Acid/Triphenylphosphine System

“…[4][5][6][7][8][9][10][11][12][13][14] which are mainly based on the reaction of acyl halides with thiocyanate ion. 2,6 Acyl halides are not always easy to access or store.…”

Efficient Approaches to S-Alkyl-N-alkylisothioureas: Syntheses of Histamine H3 Antagonist Clobenpropit and Its Analogues

“…Among isothiocyanates employed, PPI most strongly suppressed the production of amide 11a , providing 7a in 78% yield (Table , entry 1). In addition, PPI itself can be easily prepared by the one-step reaction of commercially available 3-phenylpropionyl chloride with Pb(SCN) 2 . From the results of Table and the suppression of amide formation in the first reaction, we adopted the PPI method as the general method for the synthesis of isothioureas 1 .…”