10 Ciguatera poisoning: an increasing burden for Pacific island communities in light of climate change?

Chinain, Mireille; Gatti, Clémence; Martin-Yken, Hélène; Roué, Mélanie; Darius, Hélène Taiana

doi:10.1515/9783110625738-010

Cited by 6 publications

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“…Additionally, consumption of a toxic Acanthurus xanthopterus specimen estimated at 0.24 µg CTX1B eq. kg −1 was associated with gastrointestinal, neurological, muscular, and articular clinical manifestations in another patient [51]. Thus, the seven positive deep-water specimens would be unsafe for consumption.…”

Section: Resultsmentioning

confidence: 96%

“…Using the rRBA, the lowest CTX content found in fish remnants involved in ciguatera cases from French Polynesia was 0.16 µg CTX1B eq. kg −1 (clinical symptoms not available) [51]. Additionally, consumption of a toxic Acanthurus xanthopterus specimen estimated at 0.24 µg CTX1B eq.…”

Section: Resultsmentioning

confidence: 99%

“…Despite the low number of specimens analyzed per species and per site in this study and the limitation inherent to the use of different extraction protocols, evidence for the presence of CTXs in several of the deep-water fish species at levels 4 to 282 times higher than the guidance level of 0.01 µg CTX1B kg −1 recommended by the US FDA and EFSA [36,75] and above 0.16 µg CTX1B eq. kg −1 found in fish remnants in French Polynesia [51] highlights the potential health risk associated with the consumption of these fish in French Polynesia.…”

Section: Contribution Of Deep-water Fish To the Trophic Chain Of Ciguateramentioning

confidence: 92%

“…Of note, 52-epi-54-deoxyCTX1B and 54-deoxyCTX1B were originally given the names CTX-2 and CTX-3, respectively [46]. For the record, CTX1B and the two deoxy analogs of CTX1B (Figure 4), 52-epi-54-deoxyCTX1B and 54-deoxyCTX1B, are usually found in a variety of great carnivores such as moray eels, barracudas, groupers, snappers, Spanish mackerels, or jacks in the Asia-Pacific region [43][44][45][46]51,[56][57][58][59][60][61][62][63][64]. However, these analogs were also reported in herbivorous and omnivorous coral reef fish species [53,61].…”

Section: Ciguatoxin Profiles As Assessed By Lc-ms/msmentioning

confidence: 99%

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Deep-Water Fish Are Potential Vectors of Ciguatera Poisoning in the Gambier Islands, French Polynesia

et al. 2021

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Ciguatera poisoning (CP) cases linked to the consumption of deep-water fish occurred in 2003 in the Gambier Islands (French Polynesia). In 2004, on the request of two local fishermen, the presence of ciguatoxins (CTXs) was examined in part of their fish catches, i.e., 22 specimens representing five deep-water fish species. Using the radioactive receptor binding assay (rRBA) and mouse bioassay (MBA), significant CTX levels were detected in seven deep-water specimens in Lutjanidae, Serranidae, and Bramidae families. Following additional purification steps on the remaining liposoluble fractions for 13 of these samples (kept at −20 °C), these latter were reanalyzed in 2018 with improved protocols of the neuroblastoma cell-based assay (CBA-N2a) and liquid chromatography tandem mass spectrometry (LC–MS/MS). Using the CBA-N2a, the highest CTX-like content found in a specimen of Eumegistus illustris (Bramidae) was 2.94 ± 0.27 µg CTX1B eq. kg−1. Its toxin profile consisted of 52-epi-54-deoxyCTX1B, CTX1B, and 54-deoxyCTX1B, as assessed by LC–MS/MS. This is the first study demonstrating that deep-water fish are potential ciguatera vectors and highlighting the importance of a systematic monitoring of CTXs in all exploited fish species, especially in ciguatera hotspots, including deep-water fish, which constitute a significant portion of the commercial deep-sea fisheries in many Asian–Pacific countries.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Contribution Of Deep-water Fish To the Trophic Chain Of Ciguateramentioning

confidence: 92%

Section: Ciguatoxin Profiles As Assessed By Lc-ms/msmentioning

confidence: 99%

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Deep-Water Fish Are Potential Vectors of Ciguatera Poisoning in the Gambier Islands, French Polynesia

et al. 2021

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“…Unfortunately, the limited sample volumes remaining from other technique, as well as the relatively low concentrations of individual CTX compounds present in our samples, together with the matrix effect, did not allow us to make any further clarification on the toxin profile of CTX-exposed fish. In French Polynesia, CTX composition of steephead parrotfish C. microrhinos typically includes CTX3C type compounds (71.1% as CTX3C and its M-seco form) and, to a lesser extent, CTX4A type (28.8% as CTX4A and its M-seco form) [ 33 , 54 ]. However, CTX profiles in fish are species-specific and can differ from regional variations [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Experimental Evidence of Ciguatoxin Accumulation and Depuration in Carnivorous Lionfish

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Sdiri

Taylor

et al. 2021

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Ciguatera poisoning is a food intoxication associated with the consumption of fish or shellfish contaminated, through trophic transfer, with ciguatoxins (CTXs). In this study, we developed an experimental model to assess the trophic transfer of CTXs from herbivorous parrotfish, Chlorurus microrhinos, to carnivorous lionfish, Pterois volitans. During a 6-week period, juvenile lionfish were fed naturally contaminated parrotfish fillets at a daily dose of 0.11 or 0.035 ng CTX3C equiv. g−1, as measured by the radioligand-receptor binding assay (r-RBA) or neuroblastoma cell-based assay (CBA-N2a), respectively. During an additional 6-week depuration period, the remaining fish were fed a CTX-free diet. Using r-RBA, no CTXs were detectable in muscular tissues, whereas CTXs were measured in the livers of two out of nine fish sampled during exposure, and in four out of eight fish sampled during depuration. Timepoint pooled liver samples, as analyzed by CBA-N2a, confirmed the accumulation of CTXs in liver tissues, reaching 0.89 ng CTX3C equiv. g−1 after 41 days of exposure, followed by slow toxin elimination, with 0.37 ng CTX3C equiv. g−1 measured after the 6-week depuration. These preliminary results, which need to be pursued in adult lionfish, strengthen our knowledge on CTX transfer and kinetics along the food web.

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Improving in vitro ciguatoxin and brevetoxin detection: selecting neuroblastoma (Neuro-2a) cells with lower sensitivity to ouabain and veratridine (OV-LS)

et al. 2021

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10 Ciguatera poisoning: an increasing burden for Pacific island communities in light of climate change?

Cited by 6 publications

References 0 publications

Deep-Water Fish Are Potential Vectors of Ciguatera Poisoning in the Gambier Islands, French Polynesia

Deep-Water Fish Are Potential Vectors of Ciguatera Poisoning in the Gambier Islands, French Polynesia

Experimental Evidence of Ciguatoxin Accumulation and Depuration in Carnivorous Lionfish

Improving in vitro ciguatoxin and brevetoxin detection: selecting neuroblastoma (Neuro-2a) cells with lower sensitivity to ouabain and veratridine (OV-LS)

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