10 Neuroendocrinology of the hypothalamo—pituitary—adrenal axis in pregnancy and the puerperium

Smith, Roger; Thomson, Murray

doi:10.1016/s0950-351x(05)80102-8

Cited by 53 publications

(44 citation statements)

References 77 publications

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“…All studies recommended a lower cutoff point toward the end of pregnancy, which may reflect the changing neurobiology underlying depression as the end of term approaches [32][33][34]. In the current study, the PPV decreased toward end term even with the use of lower cutoff scores.…”

Section: Discussionmentioning

confidence: 57%

Validation of the Edinburgh Depression Scale during pregnancy

Bergink

Kooistra

Berg

et al. 2011

Journal of Psychosomatic Research

500

380

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Section: Discussionmentioning

confidence: 57%

Validation of the Edinburgh Depression Scale during pregnancy

Bergink

Kooistra

Berg

et al. 2011

Journal of Psychosomatic Research

500

380

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“…Indeed, there is evidence that normal pregnancy is associated with glucocorticoid resistance, as indicated by studies showing impaired GR-mediated negative-feedback regulation of the HPA axis [18], and reduced GR function [19]. Consistent with this, both the HPA axis and the inflammatory system are hyperactive during normal pregnancy.…”

Section: Clinical Relevance Of Antenatal Depressionmentioning

confidence: 83%

Depression during pregnancy: molecular regulations of mothers’ and children's behaviour

Pariante

2014

Biochemical Society Transactions

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Depression in pregnancy (also called 'antenatal depression') is being increasingly recognized as a clinically relevant condition that affects obstetric outcome, maternal behaviour and children's future mental health. The present review focuses on the molecular mechanisms operating in utero that underlie the potential effects of antenatal depression on mothers' and children's behaviour. In particular, I discuss evidence, coming largely from animal and cellular studies, that activation of the main hormonal stress-response system, the HPA (hypothalamic-pituitary-adrenal) axis, in mothers who are depressed during pregnancy may affect maternal care as well as offspring's behaviour and future psychopathology. The evidence summarized in the present review supports the notion that preventing or treating depression in pregnancy will alleviate not only the suffering of mothers, but also the suffering of the next generation.

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“…Micrographs were taken with a digital camera (Nicon Coolpix 4500). Since -endorphin production has been previously confirmed in the central nervous system, [14][15][16] pituitary gland sections were used as a positive control; this preparation was achieved by fixation in 4% paraformaldehyde. After 24-48 h the biopsy was embedded in paraffin and sliced to a 5-mm thickness onto positively-charged slides.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Detection of mRNA transcripts of truncated opiate precursor (POMC) in human cartilage

Andjelkov

Elvenes

Figenschau

et al. 2006

Cell Biochem. Funct.

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In the present study, we have investigated the presence of pro-opiomelanocortin C-terminal fragment derived-peptides in human articular cartilage and cultured chondrocytes. beta-Lipotropin and beta-endorphin were monitored in different cell cultures and biopsies using different techniques. Biopsies were taken from patients undergoing total knee arthroplasty due to osteoarthritis. Both fresh tissue sections and chondrocytes cultured in monolayer were used in the study. Immunohistochemistry, immunocytochemistry, reverse transcriptase-polymerase chain reaction and qualitative Western blots were carried out. The results of the reverse transcriptase-polymerase chain reaction showed transcription of a truncated-form of mRNA for pro-opiomelanocortin in native cartilage and cultured chondrocytes. There was no detection of endogenous production of beta-lipotropin or beta-endorphin in human articular chondrocytes, either in situ or in vitro. Whether pro-opiomelanocortin-derived peptides of non-cartilaginous origin are present in articular cartilage itself still remains unclear.

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10 Neuroendocrinology of the hypothalamo—pituitary—adrenal axis in pregnancy and the puerperium

Cited by 53 publications

References 77 publications

Validation of the Edinburgh Depression Scale during pregnancy

Validation of the Edinburgh Depression Scale during pregnancy

Depression during pregnancy: molecular regulations of mothers’ and children's behaviour

Detection of mRNA transcripts of truncated opiate precursor (POMC) in human cartilage

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