To achieve the most energy-efficient operation, this brief presents a circuit design technique for separating the power supply voltage (V DD ) of flip-flops (FFs) from that of combinational circuits, called the higher voltage FF (HVFF). Although V DD scaling can reduce the energy, the minimum operating voltage (V DDmin ) of FFs prevents the operation at the optimum supply voltage that minimizes the energy, because the V DDmin of FFs is higher than the optimum supply voltage. In HVFF, the V DD of combinational logic gates is reduced below the V DDmin of FFs while keeping the V DD of FFs at their V DDmin . This makes it possible to minimize the energy without power and delay penalties at the nominal supply voltage (1.2 V) as well as without FF topological difications. A 16-bit integer unit with HVFF is fabricated in a 65-nm CMOS process, and measurement results show that HVFF reduces the minimum energy by 13% compared with the conventional operation, which is 1/10 times smaller than the energy at the nominal supply voltage.Index Terms-Minimum operating voltage, subthreshold circuits, variations.