1240 LARGE INTRAVENTRICULAR HEMORRHAGE (IVH) AND LABOR IN INFANTS ≥11000g

Bejar, Raul; Curbelo, Violeta; Coen, Ronald W.; Gluck, Louis

doi:10.1203/00006450-198104001-01267

Cited by 3 publications

(4 citation statements)

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“…The increased synthesis of prostaglandins to induce preterm labour is one hypothesized mechanism of M hominis. This association is supported by findings of Bejar et al [1], who has measured a phospholipase A2 activity for M hominis. PLA2 is a key enzyme in the synthesis cascade of prostaglandins.…”

Section: Discussionsupporting

confidence: 71%

“…Thus, we could not find M hominis strain differences in the vaginal flora of women with normal pregnancy and preterm labour. Moreover, with these results we disprove the findings of Bejar et al [1] and can now finally exclude a role of M hominis in the induction of preterm uterine contractions via PLA2 activity. To clarify the role of M hominis in causing prematurity definitively, other pathways like the induction of cytokine production have to be investigated [4,10].…”

Section: Discussioncontrasting

confidence: 40%

“…Mycoplasma hominis (M hominis) is one of the species that are thought to be able to induce preterm labour, although the association between vaginal colonization with M hominis and prematurity is doubtful [2,3,6,7,8]. The assumption that M hominis is involved in the induction of preterm uterine contractions is based on a phospholipase A2 (PLA2) activity that has been described [1]. However, this is unlikely, because PLA2 is an enzyme only found in eukaryontics.…”

Section: Introductionmentioning

confidence: 97%

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Absence of phospholipase A2 activity in genital Mycoplasma hominis

Walther¹,

Stepan²,

Baumann³

et al. 1998

Jpme

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The clinical relevance of vaginal colonization with Mycoplasma hominis (M hominis) as a cause of prematurity is doubtful. One of the possible pathways which could explain the role of M hominis in the induction of preterm labour is an increased synthesis of prostaglandins by a phospholipase A2 activity. The aim of this study was to prove whether M hominis secrets proteins with a PLA2 activity and to test whether there are strain differences in the enzyme activity between M hominis isolated from women with normal pregnancy and those with preterm labour. Using specific radio-immunoassay we could not measure any PLA2 activity in the supernatant of all investigated M hominis strains. We exclude the mechanism of induction of preterm labour by M hominis via an increased prostaglandin synthesis. Our findings make a relation between vaginal colonization with M hominis and prematurity unlikely.

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Section: Discussionsupporting

confidence: 71%

Section: Discussioncontrasting

confidence: 40%

Section: Introductionmentioning

confidence: 97%

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Absence of phospholipase A2 activity in genital Mycoplasma hominis

Walther¹,

Stepan²,

Baumann³

et al. 1998

Jpme

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“…416 Thus, Bejar et al observed a higher incidence of "larger hemorrhages" in infants of mothers who were in labor prior to delivery. 17 In our study, the same proportion of mothers were in labor before delivery in the group of infants which developed SEH/IVH as in those that did not. Furthermore, labor did not affect the incidence of SEH/IVH in the different presentations, for example, vertex or breech.…”

Section: Discussionsupporting

confidence: 57%

Perinatal Factors that Influence the Incidence of Subependymal and Intraventricular Hemorrhage in Low Birthweight Infants

Dolfin¹,

Skidmore²,

Fong³

et al. 1984

Amer J Perinatol

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A total of 95 preterm infants, delivered consecutively in a perinatal center, over a 9-month period, were studied serially with real-time ultrasound for detection of subependymal/intraventricular hemorrhage (SEH/IVH); all infants were less than or equal to 32-week gestation and/or less than or equal to 1500 gm birthweight. Detailed statistical analysis was carried out to determine the influence of perinatal factors on the occurrence of SEH/IVH. The incidence of SEH/IVH was 34%; severe hemorrhage (Grade III-IV) occurred in only 13%. Gestational age was an important factor associated with SEH/IVH. Thus, the incidence in infants less than or equal to 29-weeks gestation was 45%, whereas in infants greater than 29-weeks gestation age, it was 19% (p less than 0.01). The overall incidence of SEH/IVH in the group which was less than or equal to 29-weeks gestation and delivered by cesarean section was 53%, whereas in those infants delivered vaginally it was 47%. In infants whose gestational age was less than or equal to 29-weeks, the incidence of hemorrhage was 47% if delivered vaginally and presenting as a vertex and 31% if delivered by cesarean section. In infants greater than 29-weeks gestation, the incidence of SEH/IVH was 42% in those delivered by the vaginal vertex route, 5% if presentation was vertex and delivered by cesarean section (p less than 0.05). In infants greater than 29-weeks gestation, cesarean section in vertex presentation decreased the incidence of SEH/IVH when compared with vaginal vertex delivery.(ABSTRACT TRUNCATED AT 250 WORDS)

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Anterior fontanel: Window to the neonatal brain

Volpe

1982

The Journal of Pediatrics

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1240 LARGE INTRAVENTRICULAR HEMORRHAGE (IVH) AND LABOR IN INFANTS ≥11000g

Cited by 3 publications

References 0 publications

Absence of phospholipase A2 activity in genital Mycoplasma hominis

Absence of phospholipase A2 activity in genital Mycoplasma hominis

Perinatal Factors that Influence the Incidence of Subependymal and Intraventricular Hemorrhage in Low Birthweight Infants

Anterior fontanel: Window to the neonatal brain

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