13C-Aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C

Rocco, Alba; Nucci, Germana de; Valente, Giovanna; Compare, Debora; D’Arienzo, A.; Cimino, L.; Perri, Francesco; Nardone, Gerardo

doi:10.1016/j.jhep.2011.10.015

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…In our study, we found that baseline ABT was inversely associated with serum albumin levels, a marker of liver function. This finding is in line with the evidence reporting a decrease in ABT from healthy subjects to patients with chronic hepatitis and further to those with compensated cirrhosis, and confirms the reported association between ABT and liver function indexes in patients with cirrhosis …”

Section: Discussionsupporting

confidence: 92%

“…This finding is in line with the evidence reporting a decrease in ABT from healthy subjects to patients with chronic hepatitis and further to those with compensated cirrhosis, 7 and confirms the reported association between ABT and liver function indexes in patients with cirrhosis. 8 The main challenge when treating patients with HCV-related advanced cirrhosis is to identify those where SVR will improve clinical outcomes from their counterpart that will not have clinical benefits. In our study, to the best of our knowledge, we firstly demonstrated that Ʌ ABT from SVR12 to baseline is able to independently and accurately predict the occurrence of liver-related events/death after SVR.…”

Section: Discussionmentioning

confidence: 99%

“…13 C‐aminopyrine breath test (ABT) is a dynamic test exploring the global liver function activity. A decrease in ABT has been associated with the presence of hepatic cirrhosis and poor liver function indexes …”

Section: Introductionmentioning

confidence: 99%

“…A decrease in ABT has been associated with the presence of hepatic cirrhosis 7 and poor liver function indexes. 8 With this in mind, we used ABT, a non-invasive method evaluating microsomal hepatocellular function, at baseline and after SVR, to assess whether its changes can predict liver-related outcomes after DAA treatment in patients with advanced HCV cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

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Aminopyrine breath test predicts liver‐related events and death in HCV‐related cirrhosis on SVR after DAA therapy

Petta

Rini

Calvaruso

et al. 2019

Liver International

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Background & Aims In patients with hepatitis C virus (HCV)‐related advanced cirrhosis, the effects of sustained virological response (SVR) by direct antiviral agents (DAAs) on decompensation and liver deaths are less clearcut, since up to 30% of patients do not improve, and no predictors of outcome have been identified. We used 13C‐aminopyrine breath test (ABT) to assess whether its changes can predict liver‐related outcomes after DAA treatment in patients with HCV cirrhosis. Methods Fifty consecutive patients with HCV cirrhosis were enrolled. Patients were included if they had Child A cirrhosis at risk for decompensation – defined as Child A6 (N = 22, 44%) or previous decompensation (N = 7, 14%) – or Child B cirrhosis (N = 21, 42%) eligible for DAA‐based antiviral therapy. ABT was performed at baseline and 12 weeks after the end of antiviral therapy. Patients received sofosbuvir‐based regimens. Results Aminopyrine breath test was available for all 50 patients at baseline. The 120’ cumulative dose was directly associated at regression analysis only with albumin levels (P = .001). ABT was available at follow‐up week 12 for 41 patients (FUW12), all with SVR, and followed for a median of 25.2 months (range 12.2‐32.1 months). Lower Ʌ ABT – defined as changes of 120’ cumulative dose from FUW12 to baseline – (HR 0.97, 95% CI 0.94‐0.99; P = .02) and FUW12 hepatic encephalopathy (HR 19.0, 95% CI 1.16‐310.3; P = .03) were the only independent predictors of liver events/death at multivariate Cox regression analysis. The AUC of Ʌ ABT was good (0.87, 95% CI 0.75‐0.97), with a delta ≥0% well discriminating patients at lower vs patients at higher risk of liver‐related events/death (P < .001). Conclusions In patients with advanced HCV cirrhosis who achieve SVR with DAA, Ʌ ABT assists in assessing the residual likelihood of liver‐related events and deaths after viral cure.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aminopyrine breath test predicts liver‐related events and death in HCV‐related cirrhosis on SVR after DAA therapy

Petta

Rini

Calvaruso

et al. 2019

Liver International

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“…Breath tests are infrequently used and involve an oral or intravenous load of a radiolabeled substance (e.g., 13 C‐ or 14 C‐aminopyrine, 14 C‐galactose) that is predominately metabolized in the liver. Exhaled carbon dioxide (CO 2 ) is collected in an alkaline medium at serial intervals and the activity of 14 CO 2 is measured.…”

Section: Other Functional Tessmentioning

confidence: 99%

The holy grail of a biomarker for “liver function”

Majumdar

Pinzani

2016

Clinical Liver Disease

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The past decade has given rise to many innovations in hepatology, particularly in the fields of noninvasive fibrosis assessment and viral hepatitis. Comparatively, advances in the functional assessment of the liver have progressed at a much slower rate. It is an ambitious proposal to develop a single unifying biomarker to assess global liver function, but one that highlights the inadequacies of current methods of assessment. A major impediment to the pursuit of this ''holy grail'' is the broad range of functions performed by the liver. Moreover, liver function per se is only one determinant of prognosis in chronic liver diseases, with portal hypertension and hepatocarcinogenesis being two other major factors. For this reason, any progress in the pure functional assessment of the liver has been made predominantly in the settings of acute liver failure and the preoperative assessment for liver resection. This brief review aims to discuss the current and future status of the hepatic functional assessment.

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Deuterium‐ und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften

Atzrodt¹,

Derdau²,

Kerr

et al. 2018

Angewandte Chemie

108

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Wasserstoffisotope sind einzigartige Werkzeuge zur Identifizierung und Erforschung biologischer oder chemischer Vorgänge. Wasserstoffisotopenmarkierungen erlauben den spurlosen und direkten Einbau einer zusätzlichen Masseneinheit oder eines radioaktiven Markers in ein organisches Molekül, und dies praktisch ohne Änderungen der chemischen Struktur, der physikalischen Eigenschaften oder der biologischen Aktivität. Die Verwendung von deuteriummarkierten Isotopologen zur Untersuchung der spezifischen massenspektrometrischen (MS) Muster, die von Gemischen biologisch relevanter Moleküle hervorgerufen werden, ermöglicht eine drastische Vereinfachung der Analyse. Solche Methoden ermöglichen nun tiefe Einblicke in einen großen, kontinuierlich anwachsenden Bereich von Anwendungen in den Biowissenschaften und darüber hinaus. Speziell Tritium (3H) wird zunehmend eingesetzt, insbesondere in der pharmazeutischen Wirkstoffsuche. Aufwand und Kosten der Synthese markierter Verbindungen werden durch die hohe Empfindlichkeit der Analyse und hohe Zuverlässigkeit der erhaltenen Daten mehr als ausgeglichen. In diesem Aufsatz werden Fortschritte bei der Verwendung von Wasserstoffisotopen in den Biowissenschaften beschrieben.

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13C-Aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C

Cited by 13 publications

References 35 publications

Aminopyrine breath test predicts liver‐related events and death in HCV‐related cirrhosis on SVR after DAA therapy

Aminopyrine breath test predicts liver‐related events and death in HCV‐related cirrhosis on SVR after DAA therapy

The holy grail of a biomarker for “liver function”

Deuterium‐ und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften

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