15 % Azelainsäuregel in der Behandlung der Akne. Zwei doppelblinde klinische Vergleichsstudien

Gollnick, Harald; Graupe, K.; Zaumseil, R P

doi:10.1046/j.1439-0353.2004.04731.x

Cited by 49 publications

(44 citation statements)

References 16 publications

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“…The most common side effects are local irritation, erythema, pruritus, burning and mild flaking, which tend to disappear after four weeks of treatment. [17][18][19] It can be indicated for the same clinical forms of acne and treatment conditions previously mentioned for topical retinoids, with the difference that use of azelaic acid does not present risks for pregnant and lactating women. Moreover, due to their greater efficacy compared with topical monotherapy, they also promote greater improvement in quality of life for patients with mild to moderate acne vulgaris.…”

Section: Resultsmentioning

confidence: 99%

Evidence on acne therapy

Costa

Bagatin

2013

Sao Paulo Med. J.

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Among the current treatments available for acne vulgaris, many widely practiced options lack support from studies at the best level of scientific evidence. The aim of this narrative review was to present the very latest information on topical and systemic treatments for acne vulgaris. Information from systematic reviews and well-designed clinical trials, obtained through a systematic search of the major medical databases, is emphasized. There are important issues regarding the clinical management of acne that still lack consistent grounding in scientific evidence. Among these are the optimum dose and duration of treatment with oral antibiotics that can be given without inducing bacterial resistance, and the safety of oral isotretinoin. RESUMONa terapêutica atual da acne vulgar, muitas opções amplamente praticadas carecem de respaldo em estudos de melhor nível de evidência científica. O objetivo desta revisão narrativa é apresentar o que há de mais recente no tratamento tópico e sistêmico da acne vulgar. São enfatizadas as informações de revisões sistemáticas e de ensaios clínicos com bom desenho metodológico, obtidas a partir de busca sistematizada nas principais bases de dados em medicina. Há importantes questões referentes à conduta clínica diante da acne que ainda requerem embasamento em evidências científicas consistentes, entre elas a dose e a duração ideais do tratamento com antibióticos orais, sem que ocorra indução de resistência bacteriana, e a segurança da isotretinoína oral.I MD. Doctoral student in the Postgraduate

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Section: Resultsmentioning

confidence: 99%

Evidence on acne therapy

Costa

Bagatin

2013

Sao Paulo Med. J.

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“…[30] представлены данные двух клинических исследований по изуче-нию эффективности 15% геля азелаиновой кислоты по сравнению с 5% гелем БПО и 1% гелем клинда-мицина. Авторы показали, что при применении препаратов в течение 4 нед была достигнута эффек-тивность 70% по снижению числа воспалительных элементов во всех группах.…”

Section: клиническая дерматология и венерология 1 2015unclassified

Acne and the epidermal barrier

Petrova¹,

Колбина²

2015

Klin. dermatol. venerol.

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Представлены данные о состоянии эпидермального барьера и рогового слоя эпидермиса у больных акне. Обсуждается влияние различных компонентов препаратов для наружной терапии акне на состояние эпидермального барьера. Ключевые слова: акне, эпидермальный барьер, сквалан, азелаиновая кислота, Азелик.The article presents the data on the condition of the epidermal barrier and stratum corneum in patients with acne. The effect of different components of drugs used for topical treatment of acne on the epidermal barrier condition is discussed.

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“…Topical azelaic acid 15% gel and 20% cream also have been found to effectively reduce inflammatory and non-inflammatory acne lesions (18,19). Efficacy has been reported to be comparable to tretinoin 0.05% cream, BPO 5% gel, clindamycin 1%, and erythromycin 2% ointment (18,19).…”

Section: Topical Therapymentioning

confidence: 99%

“…Efficacy has been reported to be comparable to tretinoin 0.05% cream, BPO 5% gel, clindamycin 1%, and erythromycin 2% ointment (18,19). Because azelaic acid is generally well tolerated and has a low potential for irritation, it is an appropriate therapeutic option for patients with sensitive skin or a history of PIH (1,18).…”

Section: Topical Therapymentioning

confidence: 99%

Acne in skin of color: Practical approaches to treatment

Shah

Alexis

2010

Journal of Dermatological Treatment

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Acne vulgaris, one of the most commonly encountered conditions in dermatology, affects individuals in all racial and ethnic groups, yet clinical presentation varies among different skin types. Acne, particularly when it is severe, may significantly impact an individual's quality of life and psychological well-being. Potential sequelae, such as postinflammatory hyperpigmentation and keloid scarring, occur more frequently in individuals with skin of color and may be long lasting or permanent. Acknowledging the potentially long-term physical and emotional scars caused by acne vulgaris, attention has focused on management strategies that limit the disease to an early stage. Early and efficacious treatment of acne in skin of color patients may minimize pigmentary abnormalities and keloid scarring. By recognizing racial and ethnic differences in clinical presentation and potential sequelae, treatment regimens may be tailored to ensure favorable outcomes for patients of all skin types.

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15 % Azelainsäuregel in der Behandlung der Akne. Zwei doppelblinde klinische Vergleichsstudien

Abstract: Azelaic acid gel is an effective topical monotherapy for mild-to-moderate acne vulgaris; its new gel form is an enrichment of acne therapy.

Cited by 49 publications

References 16 publications

Evidence on acne therapy

Evidence on acne therapy

Acne and the epidermal barrier

Acne in skin of color: Practical approaches to treatment

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