a b s t r a c tWe present a new method that quantifies the oxygen isotope geochemistry of Laurentide ice-sheet (LIS) meltwater across the last deglaciation, and reconstruct decadal-scale variations in the d 18 O of LIS meltwater entering the Gulf of Mexico between~18 and 11 ka. We employ a technique that combines laser ablation ICP-MS (LA-ICP-MS) and oxygen isotope analyses on individual shells of the planktic values of Mississippi River discharge from discrete core intervals range from À22‰ to À38‰ VSMOW. These values suggest a dynamic melting history of different parts of the LIS, with potential contributions to Mississippi River outflow from both the low-elevation, southern margin of the LIS and high-elevation, high-latitude domes in the LIS interior that were transported to the ablation zone. Prior to~15.5 ka, the d 18 O water value of the Mississippi River was similar to that of regional precipitation or low-latitude LIS meltwater, but the Ba concentration in the Mississippi basin was affected by changes in weathering within the watershed, complicating Ba-salinity relationships in the Gulf of Mexico. After 13 ka, our data suggest Mississippi River outflow did not influence surface salinity above our Gulf of Mexico Orca Basin core site. Rather, we hypothesize that open ocean conditions prevailed as sea level rose and the paleoshoreline at the southern edge of North America retreated northward.