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Farizal, Jon; Dewa, Exchagusesa Abdul Rahman Serbasa

doi:10.29238/teknolabjournal.v6i2.44

Cited by 9 publications

(9 citation statements)

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“…8 Komposisi senyawa flavonoid, tanin, saponin yang terdapat di kulit kayu rambutan dapat menghambat pertumbuhan jamur Candida albicans. 9,17 Hasil penelitian ini menunjukkan adanya efektivitas ekstrak kulit kayu rambutan terhadap pertumbuhan Candida albicans dengan KHM pada konsentrasi 20% dan KFM pada konsentasi 40%. Zona hambat yang terbentuk oleh ekstrak kulit kayu rambutan pada konsentrasi 40 dan 80% dengan diameter zona hambat masing-masing adalah 10,2 dan 12,9 mm, namun zona hambat yang terbentuk itu masih lebih kecil dari zona hambat yang dihasilkan Flukonazole seluas 24,2 mm.…”

Section: Pembahasanunclassified

Efektivitas ekstrak kulit kayu rambutan (Nephelium lappaceum L.) terhadap Candida albicansThe effectiveness of rambutan (Nephelium lappaceum L.) bark extract on the growth of Candida albicans

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et al. 2021

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Pendahuluan: Ekstrak kulit kayu rambutan memiliki senyawa aktif yang digunakan sebagai antijamur terutama pada Candida albicans. Candida albicans pada rongga mulut dapat menyebabkan kandidiasis lidah. Salah satu faktor predisposisi yang memicu kandidiasis adalah terganggunya ekologi mulut atau perubahan mikrobiologi mulut karena pemakaian antibiotika dalam waktu yang lama oleh karena itu diperlukan antibiotik berbahan herbal yang dapat digunakan secara topikal. Tujuan penelitian ini untuk mengetahui efektivitas daya hambat ekstrak kulit kayu rambutan terhadap pertumbuhan Candida albicans pada konsentrasi 80%, 40%, 20%,10%, konsentrasi minimum daya hambat (KHM) dan daya bunuh (KBM) ekstrak kulit kayu rambutan terhadap Candida albicans. Metode: Penelitian ini merupakan eksperimental laboratoris dengan rancangan penelitian post test only control group design. Sampel yang digunakan adalah Candida albicans yang diisolasi dari penderita kandidiasis lidah dan dibiakkan di Laboratorium Mikrobiologi RS USU. Pengujian efektivitas ekstrak kulit kayu rambutan terhadap pertumbuhan Candida albicans dengan metode dilusi dan difusi, ekstrak kulit kayu rambutan dibuat dengan teknik maserasi menggunakan pelarut etanol 70% dengan berbagai konsentrasi (80%, 40%, 20% dan 10%). Hasil: uji Kruskal- Wallis menunjukkan perbedaan zona hambat yang signifikan pada beberapa konsentrasi. KHM Ekstrak kulit kayu rambutan diperoleh 20%, dan KBM 40%. Simpulan: bahwa ekstrak kulit kayu rambutan memiliki efektivitas antijamur terhadap Candida albicans.Kata kunci: kulit kayu rambutan, KHM, KBM, Zona hambat, Candida albicans.

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Efektivitas ekstrak kulit kayu rambutan (Nephelium lappaceum L.) terhadap Candida albicansThe effectiveness of rambutan (Nephelium lappaceum L.) bark extract on the growth of Candida albicans

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et al. 2021

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“…C. albicans is the most often isolated species in humans (Listiyawati et al 2017). It usually causes candidiasis, an acute and subacute fungal disease affecting the skin of the mouth, vagina, nails, skin, bronchi, or lungs (Farizal 2017).…”

Section: Introductionmentioning

confidence: 99%

Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin

et al. 2021

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Abstract. Batubara R, Wirjosentono B, Siregar AH, Harahap U, Tamrin. 2021. Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin. Biodiversitas 22: 2884-2890. Agarwood plants (Aquilaria malaccensis Lamk.) provide numerous benefits and have been cultivated by the people. The leaves containing various compounds, such as flavonoids, glycosides, triterpenoids and tannins with antibacterial and antifungal activities, were reported to be potential for flesh wound healing. Therefore, research on these activities against microorganisms that cause infection in wounds was carried out in vitro. This research aims to determine the antibacterial and antifungal activities of agarwood leaves ethanol extract against three bacteria species (Staphylococcus epidermidis, Staphylococcus aureus, and Propionibacterium acnes) and two fungi species (Candida albicans and Trichophyton sp.) that commonly cause skin infection. The results of this research show that the concentration of ethanol extract of agarwood leaves affected the bacterial and fungal growth inhibition zone’s diameter. The best inhibitory potential occurred at 5% concentration in activity against bacteria and fungi. The extract’s active compounds contributing to the antimicrobial activity were the flavonoids and tannins. Furthermore, GC-MS identification shows that the ethanol extract from agarwood leaves contained Disulfide, dioctyl; 6,7-Dimethylquinoxaline; (E)-1,3-Di-m-tolylallyl ethyl Carbonate; 5-(2-Methoxyphenyl)-1,2-dihydropyrazol-3-one; 9-[(tert-Butyldimethylsilyl)oxy]benzo[3,4]cyclod ec-3-ene-1,5-diyne; Neophytadiene, 2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, [R-[R*,R*-(E)]]-; Hexadecanoic acid, methyl ester and a-(3-chloro-4-hydroxyphenyl)-aphenoxy-a-phenyl acetonitrile

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“…The following supporting information can be downloaded at: , Table S1: Complete search strategies for each database and grey literature; Table S2: Excluded studies and reason for exclusion (n = 47); Table S3: Quality assessment of the individual included studies (n = 12) using The Joanna Briggs Institute Critical Appraisal Checklist for Cross-sectional Studies. References [ 3 , 5 , 8 , 11 , 17 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ] are cited in the supplementary materials .…”

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Enrichment of Acid-Associated Microbiota in the Saliva of Type 2 Diabetes Mellitus Adults: A Systematic Review

et al. 2023

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It could conceivably be hypothesized that a link exists between an altered microbiota due to local hyperglycemia and the increased risk of caries in diabetes mellitus (DM). This systematic review aimed to perform a cross-study comparison into the salivary microbiota of adults with type 2 diabetes mellitus (T2D) compared to adults without T2D, particularly focusing on the abundance of acid-associated bacteria. This report follows PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Studies using next-generation sequencing and other molecular techniques are included. The methodological quality of individual studies was assessed using appropriate Joanna Briggs Institute tools. The certainty of the evidence considering the effect direction was evaluated using the GRADE approach. From 2060 titles retrieved, 12 were included in the data synthesis, totalling 873 individuals with T2D and controls evaluated across the literature. Weighted averages of blood glucose levels (HbA1c—fasting blood glucose) were 8.21%—172.14 mg/dL and 5.12%—84.53 mg/dL for T2D and controls, respectively. In most studies, the relative abundance of acidogenic and aciduric bacteria was higher in diabetics when compared to their normoglycaemic controls. Whilst the evidence certainty was very low, there was a consistent Proteobacteria depletion and Firmicutes enrichment in T2D. As for the acid-associated genera, there was consistent enrichment of Lactobacillus and Veillonela for T2D. Tannerella/T. forsythia was enriched in T2D saliva, but the certainty is low. Further well-designed cohorts are needed to clarify the distribution of acid-associated microorganisms in the saliva of adults with T2D and how this can be clinically manifested (PROSPERO = CRD42021264350).

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Cited by 9 publications

References 3 publications

<p>Efektivitas ekstrak kulit kayu rambutan (Nephelium lappaceum L.) terhadap Candida albicans</p><p>The effectiveness of rambutan (Nephelium lappaceum L.) bark extract on the growth of Candida albicans<p>

<p>Efektivitas ekstrak kulit kayu rambutan (Nephelium lappaceum L.) terhadap Candida albicans</p><p>The effectiveness of rambutan (Nephelium lappaceum L.) bark extract on the growth of Candida albicans<p>

Bioactive compounds of ethanol extract from agarwood leaves (Aquilaria malaccensis) and antimicrobial activity against bacteria and fungi growing on the skin

Enrichment of Acid-Associated Microbiota in the Saliva of Type 2 Diabetes Mellitus Adults: A Systematic Review

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