1994
DOI: 10.1016/0006-2952(94)90301-8
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2,6-Dichloro-4-nitrophenol (DCNP), an alternate-substrate inhibitor of phenolsulfotransferase

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Cited by 26 publications
(12 citation statements)
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“…The inhibitory activity of these compounds was observed to be greater than that of 2,6-dichloro-4-nitrophenol (DCNP), a specific inhibitor of mammalian PST activity (IC 50 of mouse intestinal PST activity = 30 µM). 10,13) Less inhibition of Caco-2 PST activity was observed compared to that of mouse intestinal PST activity (Fig. 3B).…”
Section: Inhibitory Effect Of Phenolic Environmental Estrogens On Pstmentioning
confidence: 90%
“…The inhibitory activity of these compounds was observed to be greater than that of 2,6-dichloro-4-nitrophenol (DCNP), a specific inhibitor of mammalian PST activity (IC 50 of mouse intestinal PST activity = 30 µM). 10,13) Less inhibition of Caco-2 PST activity was observed compared to that of mouse intestinal PST activity (Fig. 3B).…”
Section: Inhibitory Effect Of Phenolic Environmental Estrogens On Pstmentioning
confidence: 90%
“…The inhibition proˆles of ST inhibitors, such as DCNP and triethylamine, were unusual with regard to their eŠects on S. peregrina ST enzymes, 14) compared to mammalian HS-ST enzymes; DCNP inhibited 20E-ST activity at low concentrations (IC50= 0.61 mM), while 20E-ST activity was not reduced by 1 mM triethyamine. This inhibition proˆle is similar to that of P-ST.…”
Section: Dicussionmentioning
confidence: 97%
“…DCNP and triethylamine are recognized as speciˆc inhibitors of P-ST and HS-ST, respectively. 12,14) We measured the eŠects of these reagents on 20E and 2-naptholspeciˆc ST activity in the fat body lysate. Interestingly, 20E-ST activity was inhibited by low concentrations of DCNP (IC50=0.61 mM); however, triethylamine did not inhibit 20E-ST activity at all, even at a dose of 1 mM, even though 20E is a hydroxysteroid Fig.…”
Section: Ešects Of Inhibitors On 20e and 2-napthol-speciˆc St Activitymentioning
confidence: 99%
“…The supernatant was filtered through a 0.45 μm membrane and subjected to HPLC-radiometric detection for the sulfated conjugates. The separation of PAP 35 S from the 35 S-sulfated conjugates was as previously reported (Seah and Wong, 1994;Wong and Wong, 1996).…”
Section: Culture Of Hepg2 Cellsmentioning
confidence: 98%