2-methoxyestradiol inhibits intracerebral hemorrhage-induced angiogenesis in rats

Li, Haitao; Zhou, Hongbo; Zhong, Jian; Tang, Tao; Cui, Hanjin; Zhang, Qi-mei; Zhou, JingHua Liu Fan; Zhang, Qiang

doi:10.5137/1019-5149.jtn.18901-16.1

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…The adjacent tissues and blood vessels are also subject to the ischemic stress after cerebral hemorrhage, which further aggravates brain damage. A recent finding indicate that HIF-1α plays a critical role in ICH-induced angiogenesis [ 54 ]. Promoting cerebral angiogenesis and neurogenesis is also an important strategy to ameliorate brain functional damage after ICH.…”

Section: Mechanism Of Msc-evs/exo In the Treatment Of Ichmentioning

confidence: 99%

Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage

Zou

Liao

Dai

et al. 2023

Regenerative Therapy

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Section: Mechanism Of Msc-evs/exo In the Treatment Of Ichmentioning

confidence: 99%

Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage

Zou

Liao

Dai

et al. 2023

Regenerative Therapy

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“…As HIF‐1α target genes mediate angiogenesis, HIF‐1α inhibitors or silencing proved detrimental for new vessel formation after experimental intracerebral hemorrhage and cerebral ischemia (Li, Zhou, et al, ; Liu et al, ). In particular, HIF deficiency reduces VEGF‐A, Flk‐1, Neuropilin‐1 (NRP1), Delta‐like 4 (Dll4), CXCL12, and HMGB1 in the ischemic brains, among others affecting bone marrow endothelial progenitor cells homing and sprouting (Liu et al, ).…”

Section: Protective Role Of Hif In Cells Of the Cnsmentioning

confidence: 99%

The insights into molecular pathways of hypoxia‐inducible factor in the brain

Ostrowski

Zhang

2018

J of Neuroscience Research

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The objectives of this present work were to review recent developments on the role of hypoxia‐inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and inflammatory brain conditions. The dual nature of HIF effects appears well established, based on the accumulated evidence of HIF playing both the role of adaptive factor and mediator of cell demise. Cellular HIF responses depend on pathophysiological conditions, developmental phase, comorbidities, and administered medications. In addition, HIF‐1α and HIF‐2α actions may vary in the same tissues. The multiple roles of HIF in stem cells are emerging. HIF not only regulates expression of target genes and thereby influences resultant protein levels but also contributes to epigenetic changes that may reciprocally provide feedback regulations loops. These HIF‐dependent alterations in neurological diseases and its responses to treatments in vivo need to be examined alongside with a functional status of subjects involved in such studies. The knowledge of HIF pathways might be helpful in devising HIF‐mimetics and modulating drugs, acting on the molecular level to improve clinical outcomes, as exemplified here by clinical and experimental data of selected brain diseases, occasionally corroborated by the data from disorders of other organs. Because of complex role of HIF in brain injuries, prospective therapeutic interventions need to differentially target HIF responses depending on their roles in the molecular mechanisms of neurologic diseases.

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“…W e read the article with great interest by Li et al entitled "2-Methoxyestradiol Inhibits Intracerebral Hemorrhage-Induced Angiogenesis in Rats" (6). In this paper, Li et al reported that the Hypoxia-inducible factor-1α (HIF-1α) inhibitor, 2-Methoxyestradiol (2ME2) impaired postintracerebral hemorrhage (ICH) angiogenesis and functional recovery and again in this paper the authors consider that HIF-1α may have a protective effect against ICH-induced damage.…”

Section: To the Editor;mentioning

confidence: 99%

The hope for pandora\'s box: mesenchymal stem cells (mscs) for promoting angiogenesis in stroke and trauma brain injury

Dong

Peng²,

Luo³

et al. 2018

Turkish Neurosurgery

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2-methoxyestradiol inhibits intracerebral hemorrhage-induced angiogenesis in rats

Abstract: HIF-1? inhibitor, 2ME2, inhibited post-ICH angiogenesis by suppressing HIF-1? expression, thus exerting detrimental effects in ICH.

Cited by 5 publications

References 21 publications

Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage

Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage

The insights into molecular pathways of hypoxia‐inducible factor in the brain

The hope for pandora\'s box: mesenchymal stem cells (mscs) for promoting angiogenesis in stroke and trauma brain injury

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