20-MHz Ultrasound for Measurements of Flow-Mediated Dilation and Shear Rate in the Radial Artery

Nowicki, Andrzej; Trawiński, Z.; Gambin, Barbara; Secomski, Wojciech; Szubielski, Michal; Parol, Marzena; Olszewski, Robert

doi:10.1016/j.ultrasmedbio.2018.02.011

Cited by 5 publications

(10 citation statements)

References 44 publications

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“…The overall statistics on the clinical data of HT patients are presented in Table 1. We also included FMD data for healthy control group from the previously-measured FMD-RA 7 and the FMD-BA data published by Pyke and Tschakovsky (cf. Table 2).…”

Section: Participantsmentioning

confidence: 99%

“…A detailed description of the measurement method is presented in our previous study. 7 It should be emphasized that the average calculation time of BA and RA dilations using BAn software was about 15-20 min.…”

Section: Fmd Measurement Procedures In the Ba And Ramentioning

confidence: 99%

“…Different diagnostics involving invasive and noninvasive methods are used to determine endothelial function and peripheral vascular function. [6][7][8] One of the noninvasive methods used for this purpose is brachial artery ultrasound imaging used in order to assess vasodilatation flow-mediated dilation (FMD), depending on endothelial status. 9 Most of the previously reported FMD measurements were performed in the brachial artery (FMD-BA) with a strictly standardized protocol.…”

Section: Introductionmentioning

confidence: 99%

“…Shallow location of the RA allows for an increase of the scanning frequency to 20 MHz with superior axial resolution close to 0.1 mm. 7…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the radial and brachial artery flow-mediated dilation in patients with hypertension

Majka¹,

Parol²,

Nowicki³

et al. 2022

Adv Clin Exp Med

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Background. Blood flow-mediated dilation (FMD) is a noninvasive assessment of vascular endothelial function in humans. The study of the FMD in hypertensive (HT) patients is an important factor supporting the recognition of the early mechanisms of cardiovascular pathologies, and also of the pathogenesis related to hypertension. Objectives.To investigate whether FMD measured on the radial artery (FMD-RA) using high-frequency ultrasounds can be used as an alternative to FMD assessed with the lower frequency system on the brachial artery in patients with HT. Materials and methods.The simultaneous measurements of FMD-RA and FMD measurements in the brachial artery (FMD-BA) were performed on 76 HT patients using 20 MHz and 7-12 MHz linear array probes, and were compared to the FMD measured in healthy groups. All quantitative data are presented as mean ± standard deviation (SD); the p-values of the normality and tests for variables comparisons are listed. The agreement of the FMD-RA and FMD-BA in HT patients was assessed with the Bland-Altman method, and using the intraclass correlation coefficient (ICC). In some statistical calculations, the FMD-RA values were rescaled by dividing them by a factor of 2.Results. The mean FMD-RA and FMD-BA in HT patients were 5.16 ±2.18% (95% confidence interval (95% CI): [4.50%, 5.82%]) and 2. 13 ±1. 12% (95% CI: [1.76%, 2.49%]), respectively. The FMD-RA and FMD-BA values of HT patients were significantly different than those in respective control groups. The p-values of Mann-Whitney-Wilcoxon tests were less than 0.05. The Bland-Altman coefficient for both measurement methods, FMD-RA and FMD-BA, was 3%, and the ICC was 0.69. Conclusions.Our findings show that FMD-RA, supplementary to FMD-BA measurements, can be used to assess endothelial dysfunction in the group of HT patients. In addition, the FMD-RA measurements met the criteria of high concordance with the FMD-BA measurements.

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Section: Participantsmentioning

confidence: 99%

Section: Fmd Measurement Procedures In the Ba And Ramentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Shallow location of the RA allows for an increase of the scanning frequency to 20 MHz with superior axial resolution close to 0.1 mm. 7…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of the radial and brachial artery flow-mediated dilation in patients with hypertension

Majka¹,

Parol²,

Nowicki³

et al. 2022

Adv Clin Exp Med

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“…The firmware running on the DSP that is onboard the ULA-OP, processes the quadrature demodulated data: it performs 2D filtering and logarithmic compression for B-mode data; while it computes the 256-point Fast Fourier Transform (FFT) for each sample volume along the Doppler investigation line and extracts the complex envelope to generate the MSD profile [19]- [21].…”

Section: B Real-time Firmware/softwarementioning

confidence: 99%

Continuous Simultaneous Recording of Brachial Artery Distension and Wall Shear Rate: A New Boost for Flow-Mediated Vasodilation

Ramalli

Aizawa

Shore

et al. 2019

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Vascular ultrasound has been extensively applied in the clinical setting to noninvasively assess endothelial function by means of the so-called brachial artery flow mediated dilation (FMD). Despite the usefulness in large-scale epidemiological studies, this approach has revealed some pitfalls for assessing vascular physiology and health in individual subjects. Mainly, a reliable FMD examination should be based on the simultaneous and reliable measurement of both the stimulus, i.e. the wall shear rate (WSR), and the response, i.e. the diameter change. However, multiple technical, practical, and methodological challenges must be faced to meet this goal. In this work, we present the technical developments needed to implement a system to enable extensive and reliable clinical ultrasound FMD examination. It integrates both a hardware, i.e. an upgraded version of the ultrasound advanced open platform (ULA-OP), and a software part, i.e. a signal processing and data analysis platform. The system was applied for a two-center pilot clinical study on 35 young and healthy volunteers. Therefore, we present here the results of a statistical analysis on magnitude, time-course and kinetic parameters of WSR and diameter trends that allowed us to accurately explore the vasodilatory response to the dynamic wall shear rate changes. Our observations demonstrate that a direct and accurate estimation of WSR stimulus by multigate spectral Doppler allows understanding brachial artery vasodilatory response to reactive hyperemia. Drawing inferences on WSR stimulus from the diameter response along with an inaccurate estimation of WSR may cause further uncertainties for the accurate interpretation of the FMD response.

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Does Flow-Mediated Dilation Normalization for Base-Scaled Shear Rate Improve Its Value in Coronary Artery Disease Diagnostics?

Nowicki

Gambin

Secomski

et al. 2020

Ultrasound in Medicine & Biology

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20-MHz Ultrasound for Measurements of Flow-Mediated Dilation and Shear Rate in the Radial Artery

Cited by 5 publications

References 44 publications

Comparison of the radial and brachial artery flow-mediated dilation in patients with hypertension

Comparison of the radial and brachial artery flow-mediated dilation in patients with hypertension

Continuous Simultaneous Recording of Brachial Artery Distension and Wall Shear Rate: A New Boost for Flow-Mediated Vasodilation

Does Flow-Mediated Dilation Normalization for Base-Scaled Shear Rate Improve Its Value in Coronary Artery Disease Diagnostics?

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