2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

Abstract

recent years a surge has been seen in magnetic nanoparticles applications in several areas, particularly in biomedical field. the promising features of the iron oxide based magnetic nanoparticles make them an ideal tool for mri contrast agents, hyperthermia, and as drug delivery systems (DDs). the present paper describes the design and synthesis of Bao·6Fe 2 o 3 nanostructured meso-macroporous spherical aggregates by sol-gel method via spray drying technique. the obtained spherical aggregates have micrometric size, which let them to be carried by the bloodstream to a specific site where the drug is going to be release. the obtained hierarchical porous structure combined with the interconnected mesoporosity allow the body fluids to be transport through the aggregates; and the macroporosity allows the load of large molecules, like peptides. Furthermore, the structural and morphological characterization of the obtained Bao·6Fe 2 o 3 aggregates were carried out using X-ray diffraction and field emission scanning electron microscopy. keywords: nest-like morphology, hierarchical porous structure, drug delivery, barium hexaferrite.

Deformation and fracture of alumina ceramics with hierarchical porosity

“…The synthesis of ceramics having a hierarchical porous structure with spatial and interpenetrating structures of different configurations (cells, channels, shells, etc. [1,2,10]) is considered to be a very most promising means for creation of porous ceramic materials, as similar elements in the structure can give rise to unusual deformation modes of hierarchically organized structures as compared with conventional brittle materials [1,2,11]. Nevertheless, there is a lack of such studies because of difficulties arising upon the synthesis of such systems.…”

“…[1,2]. On the other hand, the effect of "zonal segregation" as a consequence of the active shrinkage of samples upon sintering is known [11], which consists in the partition of a sintered sample into regions (blocks) that are significantly larger than the mean particle size of the sintered material. Typically, the following two types of pore structures can be formed: one is determined by the interparticle porosity and the other by the porosity between blocks.…”