recent years a surge has been seen in magnetic nanoparticles applications in several areas, particularly in biomedical field. the promising features of the iron oxide based magnetic nanoparticles make them an ideal tool for mri contrast agents, hyperthermia, and as drug delivery systems (DDs). the present paper describes the design and synthesis of Bao·6Fe 2 o 3 nanostructured meso-macroporous spherical aggregates by sol-gel method via spray drying technique. the obtained spherical aggregates have micrometric size, which let them to be carried by the bloodstream to a specific site where the drug is going to be release. the obtained hierarchical porous structure combined with the interconnected mesoporosity allow the body fluids to be transport through the aggregates; and the macroporosity allows the load of large molecules, like peptides. Furthermore, the structural and morphological characterization of the obtained Bao·6Fe 2 o 3 aggregates were carried out using X-ray diffraction and field emission scanning electron microscopy. keywords: nest-like morphology, hierarchical porous structure, drug delivery, barium hexaferrite.

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Advances in nanotechnology observe new applications in many areas. Recently a great extent of research has been focused on the study of magnetic nanoparticles due to their potential application in areas such as bioscience and medicine. Magnetic nanoparticles are frequently used in biomedical and biotechnology applications since these particles associated to a given medicine are good candidates for drug release.In this work zeta potential measurements of both hexagonal barium ferrites (magnetic nanoparticles), and an antibiotic known as tetracycline were carried out. The knowledge of the measured values establishes the possibility of bringing the two particles together in order to adsorb the tetracycline on the magnetic nanoparticles, since the surface charge play an essential role in the adsorption of the pharmaceutical drug on nanomaterials (i.e., tetracycline on barium ferrites).Experimental results show the feasibility to adsorb tetracycline nanoparticles on barium hexaferrite solids at pH 7.0, based on the knowledge of the opposite electrical surface charge of the two solid species through the zeta potential measurement.