2139-PUB: Antihypertensive Effect of Azilsartan in Newly Diagnosed Stage 2 Diabetic Hypertensives

Abstract

Background and Aim: Coexistence of hypertension (HTN) and type 2 diabetes (T2DM) multiplies the risk of cardiovascular events. Early identification and prompt management of elevated blood pressure in T2DM has shown to improve the quality of life and to reduce the economic burden to the patients. We studied blood pressure (BP) lowering effect of Azilsartan (AZST) monotherapy in newly diagnosed stage 2 hypertensives with a history of T2DM. We also analysed its effects on blood glucose and renal indices. Methods: T2DM Subjects attending a specialized diabetes clinic, who were diagnosed with HTN for the first time, were invited to participate. Mean of 3 BP readings was considered for analysis after due consent. Subjects with stage 2 hypertension were administered AZST 40mg once daily. After 3 months they had a repeat BP recording. Subjects underwent serum creatinine, Na+, K+, fasting (FPG) and postprandrial (PPG) plasma glucose measurements at baseline and after 3moths’ of enrolment. We compared BP lowering efficacy and changes in plasma glucose and renal parameters at baseline and after 3months of AZST therapy. Diabetic, dyslipidemic and other chronic medicines were continued unchanged during the study period. Results: Inclusion criteria were met by 474 subjects (117, 25% females). Mean age and duration of diabetes were 53.3 (95% CI 52.3-54.3) and 7.03 (CI 6.6-7.5) years respectively. With AZST therapy mean SBP dropped from 152.7 (CI 151.1-154.3) mm Hg to 136.4 (CI 134.9-138.0) mm Hg (p <0.05) and the post treatment DBP declined to 79.6 (CI 78.8-80.4) mm Hg from its baseline value of 90.5 (CI 89.6-91.4) mm Hg (p <0.05). The mean baseline FPG and PPG were 158.8 (CI 154.0-163.4) mg/dL and 237.3 (CI 231.9-242.7) mg/dL in order. There was a non-significant decline in plasma glucose, but no changes were seen in eGFR or electrolytes. No adverse event was reported. Conclusion: Azilsartan monotherapy was found to be safe and effective in managing newly diagnosed stage 2 hypertension in type 2 diabetes without hampering renal function. Disclosure H. Mahapatra: None. M. Khuntia: None. S. Mishra: None. S.K. Mishra: None. R.K. Padhi: None. B. Jena: None. S. Das: None. R.K. Khatua: None. A.R. Jena: None. R. Mahapatra: None. L. Mahapatra: None. A.K. Sahoo: None. Funding Jyoti Diabetes Research Foundation

Polydopamine functionalized hydrogel beads as magnetically separable antibacterial materials

“…Amongst the various water contaminants, pathogenic microorganisms which either exist as biolms on water carrying pipelines or in planktonic (free) form are the main causative agents of waterborne infections. [3][4][5][6][7][8] Currently, the water treatment processes for removal of microorganisms rely on addition of chlorine, bromine, ozone or UV treatment. 9 Research indicates that pathogens have acquired resistance to disinfection by chlorination.…”

A Study Protocol to Assess the Correlation of Endometrial Morphology with Concerned Hormone Levels in Patients of Abnormal Uterine Bleeding

“…The study concludes that the role of endometrial thickness in the diagnosis of patients at high risk, especially with comorbid conditions, cannot be undermined. In selected cases of PMB by hysteroscopy, histopathological examination is mandatory for ruling out malignancy [10].…”

“…Bleeding is labeled as postmenopausal bleeding 12 months after the last period of menstruation (PMB). Around 3 percent of menopausal women are affected by this condition and require prompt and thorough evaluation [10].…”

Study of Pseudomonas aeruginosa PPF-1 biofilm formation using microfluidics: effect of magnesium on biofilm detachment in engineered conduits

“…Biofilm proliferation in engineered water systems is an ongoing concern for both municipal water infrastructure and medical equipment in healthcare environments. 1,2,3 Research into those systems under flow conditions is especially important due to their prevalence and known effects of flow on biofilm mechanical properties and bacterial proliferation. 4,5 Pseudomonas aeruginosa is an opportunistic pathogen primarily known for its harmful role in the lungs of cystic fibrosis (CF) patients, 6 but it also inhabits other environments, including human-made water installations.…”