28-Day oral toxicity study of the aqueous extract from spider brake (Pteris multifida Poiret) in rats

Wang, Tzu-Ching; Su, Yaping; Hsu, T.-Y.; Yang, Cheng; Lin, Chun‐Ching

doi:10.1016/j.fct.2007.03.010

Cited by 19 publications

(13 citation statements)

References 22 publications

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“…According to Wang et al, impaired organs often have abnormal atrophy [34]. The results of this study also showed a marked effect of the CsA administration in terms of the histopathological damages caused on the kidney of the rats in CsA group.…”

Section: Discussionsupporting

confidence: 54%

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

2016

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Background: Oxidative stress (OS) has been linked to the pathology of a variety of chronic and degenerative diseases. Medicinal plants contain bioactive compounds which are capable of preventing and fighting these diseases. The nephroprotective and antioxidant properties of the aqueous leaf extract of Costus afer (C.afer) against cyclosporine A CsA -induced nephrotoxicity in Wistar albino rats were investigated. Methods: Six groups of five weight-matched animals each, were used for the study. The first and second groups served as normal and toxic control and were given olive oil and CsA (50 mg/kg b.w.) orally respectively while groups 3, 4, 5 and 6 ingested 375, 750 and 1125 mg/kg b.w. aqueous leaf extract and 100 mg/kg b.w. of the Silymarin respectively one hour prior to administration of CsA 50 mg/kg b.w. Results: Treatment with C. afer extract at doses of 375, 750 and 1125 mg/kg prevented the CsA induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly (p < 0.05) reduced plasma creatinine, BUN, K + and renal malondialdehyde (MDA). Furthermore, all the doses were able to induce a significant increment (P < 0.05) of renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity, catalase(CAT), glutathione-S-tranferase (GST), serum electrolytes (Na + and HCO 3 − ), body and kidney weight. The nephroprotective effects of C.afer extract were confirmed by a reduced severity of renal cellular damage. Conclusion: Aqueous leaf extract of C.afer has a protective role against CsA-induced nephrotoxicity probably mediated through its antioxidant properties.

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Section: Discussionsupporting

confidence: 54%

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

2016

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“…The dietary fiber can retain water and enlarge the feces volume to shorten its retention time in intestine. Despite the fact that spider brake could enrich arsenic (Wang et al, 2007a), intake of spider brake did not cause liver swelling (Wang et al, 2007b). Administration of a high fat diet for a long period of time can not only weaken the LDL-C receptor scavenging effect, but also reduce the chance of acquiring liver CH and increase CH self-synthesis (Spady & Dietschy, 1985).…”

Section: Resultsmentioning

confidence: 99%

“…However, no toxic effect of spider brake on rats was found from our previous research (Wang et al, 2007b). Spider brake has various flavonoids and possesses many properties such as anti-pyretic, detoxifying, antibiotic, anti-inflammatory, anti-mutagenic (Lee & Lin, 1988), and free radical-scavenging activities (Wang et al, 2007c).…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperlipidemic activity of spider brake (Pteris multifida) with rats fed a high cholesterol diet

Wang¹,

Lin²,

Lee³

et al. 2009

Pharmaceutical Biology

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“…Elevation in the ALT level indicates the liver cell damage. 28 AST and ALP are present in many of the vital organs and also serves as an indicator for liver function. Biliary occlusion and damage can be confirmed by the alteration in the serum bilirubin level.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract

Sumithregowda¹,

Krishna²,

Honnenahally³

et al. 2017

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Chemotherapy is one of the potential treatments for prolonging the patient's life. Almost 60% of anticancer drugs are of natural origin, such as plants (i.e., camptothecines, irinotecan, and vincristine) and microorganisms (i.e., bleomycin, dactinomicines, doxorubicin Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract ABSTRACT Background: Litsea glutinosa (Lauraceae) stem bark is widely used in folk medicine as a hepatoprotective, anti-diarrheal and anti-dysenteric drug but there is a lack of information about its toxicity. Objective: To evaluate cytotoxicity and acute toxicity of the stem bark ethanol extract (BEE). Materials and Methods: In vitro cytotoxicity of BEE was measured against breast adenocarcinoma, prostate, and colon carcinoma cell lines. In the acute toxicity tests, rats received oral doses of BEE as 1000, 2000, and 3000 mg/kg body weight. Mortality, signs of toxicity, body weight, food consumption, and gross findings were observed for 14 days. Blood samples were collected from anesthetized animals and used for hematological and biochemical parameters. Histopathological study was performed using liver and kidney samples. Results: The BEE does not show significant cytotoxic effect against the tested cell lines up to the range from 5 to 320 µg/ml. In acute toxicity study, also lethality was not observed up to 3000 mg/kg b.w. No significant differences were noticed in body and organ weights and histopathology examinations between the control and treated groups. Conclusion: This study authenticates stem BEE may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and evidences the medicinal use of this plant in folk medicine.

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28-Day oral toxicity study of the aqueous extract from spider brake (Pteris multifida Poiret) in rats

Cited by 19 publications

References 22 publications

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Anti-hyperlipidemic activity of spider brake (Pteris multifida) with rats fed a high cholesterol diet

Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract

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