Nephroprotective and antioxidant effect of aqueous leaf extract of Costus Afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity

Abstract

Background: Oxidative stress (OS) has been linked to the pathology of a variety of chronic and degenerative diseases. Medicinal plants contain bioactive compounds which are capable of preventing and fighting these diseases. The nephroprotective and antioxidant properties of the aqueous leaf extract of Costus afer (C.afer) against cyclosporine A CsA -induced nephrotoxicity in Wistar albino rats were investigated. Methods: Six groups of five weight-matched animals each, were used for the study. The first and second groups served as normal and toxic control and were given olive oil and CsA (50 mg/kg b.w.) orally respectively while groups 3, 4, 5 and 6 ingested 375, 750 and 1125 mg/kg b.w. aqueous leaf extract and 100 mg/kg b.w. of the Silymarin respectively one hour prior to administration of CsA 50 mg/kg b.w. Results: Treatment with C. afer extract at doses of 375, 750 and 1125 mg/kg prevented the CsA induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly (p < 0.05) reduced plasma creatinine, BUN, K + and renal malondialdehyde (MDA). Furthermore, all the doses were able to induce a significant increment (P < 0.05) of renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity, catalase(CAT), glutathione-S-tranferase (GST), serum electrolytes (Na + and HCO 3 − ), body and kidney weight. The nephroprotective effects of C.afer extract were confirmed by a reduced severity of renal cellular damage. Conclusion: Aqueous leaf extract of C.afer has a protective role against CsA-induced nephrotoxicity probably mediated through its antioxidant properties.

Ameliorated and antioxidant effects of Fucoidan against cyclosporine A-induced kidney injury in rats

“…But, unfortunately, its clinical uses are related with some adverse side effects such as hypertension, nephrotoxicity, and hepatotoxicity ( (Inselmann et al, 1994); Andrés et al, 2000). In the present study, the levels of MDA and NO in the kidney tissues homogenates increased by CsA administration; this result is in accordance with some previous studies that documented the ROS formation and oxidative status alteration in CsA cytotoxicity (Ezejiofor et al, 2017;Mostafavi-Pour et al, 2008). Further, the association between CsA treatment and the induction of renal failure as well as with the increase of ROS, MDA, and thromboxane levels in the kidney tissue was confirmed in numerous in vivo and in vitro studies (De Arriba et al, 2009;De Hornedo et al, 2007;Wang & Salahudeen, 1994).…”

Effect of Alcoholic Extract of Salvia officinalis Leaves on some Physiological Parameters Aspects in Acrylamide-Treated Rats

“…Cyclosporine A inhibits the proliferation of human gastric cancer cells and can induce their apoptosis (Xing et al, 2016). Beside increased production of ROS, lipid hydroperoxides and a significant decrease in total antioxidants with Cys treatment confirms the role of oxidative stress in Cys induced organ toxicity (Ezejiofor et al, 2016).…”

Costus afer: A Systematic Review of Evidence-Based Data in support of Its Medicinal Relevance

“…e results reported in by Atere and Akinloye [45] are at variance with what Ezejiofor and Orisakwe also reported when they used lead as the toxic agent [44]. e antioxidant role of C. afer plant extract in these pharmacological activities cannot be overemphasized as there are several published reports to substantiate it [2,7,9,25,40,43].…”

“…In a disease state of the kidney, its detoxifying capacity is impaired. Toxicity of the Scienti ca that oral administration of aqueous C. afer leaf extract showed a significant dose-dependent reduction of serum BUN and K + [40].…”

“…Meanwhile, there was an improvement in the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione S-reductase (GSR) which shows that C. afer extract renders cardiac protection against toxicity [38]. In an in vivo nephrotoxicity model, C. afer aqueous leaf extract significantly resulted in an increase in GSH, CAT, SOD, and GST (glutathione S-transferase) activity in rats [40].…”