Except for well-known commercial production procedures,
this study
demonstrates that Ta
2
O
5
particles can be produced.
Through a series of steps, highly pure Ta
2
O
5
particles (99.45%) were produced from the raw ore. We have electrochemically
detected one of the important nitrogenous compounds present in urine,
“uric acid”, by a Ta
2
O
5
particle-modified
carbon paste electrode (Ta
2
O
5
-MCPE) using cyclic
voltammetry. The prepared electrode has shown excellent current sensitivity
at a pH of 6.0 phosphate-buffered solution. We have found that 4 mg
Ta
2
O
5
-MCPE has recorded the highest current
sensitivity of 75.75 μA. The oxidation peak current was varied
with the uric acid concentration in the range from 1 to 5 mM at 4
mg Ta
2
O
5
-MCPE. We have calculated the electrode-active
surface area for a bare carbon paste electrode and 4 mg Ta
2
O
5
-MCPE using the Randles–Sevcik equation, and
the values were found to be 0.0202 and 0.0450 cm
2
, respectively.
On the other hand, the calculated values of limit of detection and
limit of quantification were reported as 0.5937 × 10
–8
M and 1.9791 × 10
–8
M, respectively, for
the prepared 4 mg Ta
2
O
5
-MCPE. The interfere
studies revealed that the variation in the electrochemical signal
of uric acid in the presence of different metal ions was found to
be less than ±5%.