2D Zn‐Porphyrin‐Based Co(II)‐MOF with 2‐Methylimidazole Sitting Axially on the Paddle–Wheel Units: An Efficient Electrochemiluminescence Bioassay for SARS‐CoV‐2

Abstract

High electrocatalytic activity with tunable luminescence is crucial for the development of electrochemiluminescence (ECL) luminophores. In this study, a porphyrin‐based heterobimetallic 2D metal organic framework (MOF), [(ZnTCPP)Co 2 (MeIm)] (1), is successfully self‐assembled from the zinc(II) tetrakis(4‐carboxyphenyl)porphine (ZnTCPP) linker and cobalt(II) ions in the presence of 2‐methylimidazole (MeIm) by a facile one‐pot reaction in methanol at room temperature. On the basis of the experimental results and the theoretical calculations, the MOF 1 contains paddle–wheel [Co 2 (‐CO 2 ) 4 ] secondary building units (SBUs) axially coordinated by a MeIm ligand, which is very beneficial to the electron transfer between the Co(II) ions and oxygen. Combining the photosensitizers ZnTCPP and the electroactive [Co 2 (‐CO 2 ) 4 ] SBUs, the 2D MOF 1 possesses an excellent ECL performance, and can be used as a novel ECL probe for rapid nonamplified detection of the RdRp gene of SARS‐CoV‐2 with an extremely low limit of detection (≈30 aM).

Artificial Light-Harvesting System Based on Zinc Porphyrin and Benzimidazole: Construction, Resonance Energy Transfer, and Amplification Strategy for Electrochemiluminescence

“…Electrochemiluminescence (ECL) is an electrochemically triggered chemiluminescence reaction with the intensity influenced by the electrocatalytic ability and fluorescence capacity of ECL emitters. , In response to the above two main problems, various ECL amplification strategies have been developed. − For improving the electrocatalytic ability, integrating the co-reactant accelerators and luminophores in a platform − and assembling luminophores and co-reactants in a single molecular structure , are proposed as effective ECL amplification strategies. In terms of constructing robust and efficient luminophores, considering that most luminophores tend to form aggregates limiting the maximization of their optical properties, two sensible strategies have been explored to improve the photophysical properties of luminophores in the aggregated state.…”

Tuning Dimensionality of Benzimidazole Aggregates by Using Tetraoctylammonium Bromide: Enhanced Electrochemiluminescence Studies

“…Electrochemiluminescence (ECL) is an electrochemically triggered energy relaxation process, in which excited states are formed by electron transfer between active intermediates and free radicals generated by the redox of the luminophores or coreactants. , By a judicious combination of electrochemistry and chemiluminescence, ECL can be easily controlled by switching the potentials and have the high sensitivity of chemiluminescence without additional light sources. − …”

Aggregation-Induced Electrochemiluminescence Based on a Zinc-Based Metal–Organic Framework and a Double Quencher Au@UiO-66-NH2 for the Sensitive Detection of Amyloid β 42 via Resonance Energy Transfer

“…Metal–organic frameworks (MOFs) are porous materials formed by the coordination bonds of organic ligands and inorganic metal ions, which have excellent physical and chemical properties. − In recent years, MOFs have been widely used in the field of ECL due to the facile tunability of their metal ions and organic ligands, large surface area, and abundant open metal sites . Li’s group synthesized a novel porphyrin-based hetero bimetallic 2D MOF for the rapid nonamplified detection of the RdRp gene of SARS-CoV-2 . Hu’s group synthesized iron-based organic frameworks loaded with CuO nanoparticles as quenchers for the ECL signal of g -C 3 N 4 modified by CoPd nanoparticles to detect neuron-specific enolase .…”

“…30 Li's group synthesized a novel porphyrin-based hetero bimetallic 2D MOF for the rapid nonamplified detection of the RdRp gene of SARS-CoV-2. 31 Hu's group synthesized iron-based organic frameworks loaded with CuO nanoparticles as quenchers for the ECL signal of g-C 3 N 4 modified by CoPd nanoparticles to detect neuronspecific enolase. 32 Co-reaction accelerators, which can interact with co-reactants to enhance ECL emission, have attracted wide interest in the ECL field.…”