3,4-Dihydroxyphenylacetic acid and homovanillic acid in serum and cerebrospinal fluid of psychotic patients estimated by a gas chromatographic method

Simultaneous determination of two important dopamine metabolites at physiological pH by voltammetry

“…Physiological pH is very important for clinical analysis because DOPAC and HVA present in CSF and blood plasma fluids 4,[11][12][13] are stable only at this pH. 28 Further, the present modified electrode also showed higher oxidation currents with less positive potentials for them at pH 7.2.…”

“…6 Further, the concentrations of DOPAC and HVA were associated with Parkinson's disease 7 and schizophrenia, 8,9 and they are indicators of central dopaminergic activity. 10 Hence, the simultaneous determination of DOPAC and HVA from the brain fluids 4,11 and other body fluids [11][12][13] is very essential to secure human health from the critical diseases mentioned above. Earlier, chromatographic based techniques were reported for the simultaneous determination of DOPAC and HVA.…”

“…Earlier, chromatographic based techniques were reported for the simultaneous determination of DOPAC and HVA. 11,14 But, these methods involve very tedious procedures, are more time consuming and are less sensitive. Compared to these methods, the electrochemical method is less expensive, more convenient and highly selective and sensitive.…”