329 Modulation of opsin photoreceptors and circadian protein expression after blue light exposure in normal human keratinocytes

High‐energy visible light at ambient doses and intensities induces oxidative stress of skin—Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo

“…Furthermore, papillary and reticular fibroblasts respond differently to high‐dose blue light, for example, with regard to their metabolic activity . Accordingly, an opsin receptor (peropsin) sensitive for blue‐violet light was identified on human keratinocytes and fibroblasts, and opsin receptor expression was disrupted by blue light irradiation along with an oxidative stress response . In line with these findings, Regazzetti et al identified opsin 3 as the key sensor in melanocytes responsible for hyperpigmentation induced by blue light (reviewed by ).…”

“…78 Accordingly, an opsin receptor (peropsin) sensitive for blue-violet light was identified on human keratinocytes 79 and fibroblasts, 80 and opsin receptor expression was disrupted by blue light irradiation along with an oxidative stress response. 81 In line with these findings, Regazzetti et al 82 identified opsin 3 as the key sensor in melanocytes responsible for hyperpigmentation induced by blue light (reviewed by 47 ). Dendritic cells (DC) are also affected by blue light irradiation, which in vitro impairs DC maturation upon activation and subsequent allogeneic stimulatory capacity.…”