3D Bioprinting of Human Hollow Organs

Panja, Nabanita; Maji, Sumana; Choudhuri, Sabyasachi; Ali, Kazi Asraf; Hossain, Chowdhury Mobaswar

doi:10.1208/s12249-022-02279-9

Cited by 29 publications

(16 citation statements)

References 98 publications

(101 reference statements)

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“…Sheet lamination, that uses thin sheets of material cut by lasers or a sharp blade and glued together [ 6 ]. Lastly, 3D bioprinting, a method that creates functional human tissue for medical applications, such as drug testing and transplants [ 3 , 7 , 8 ]. Three-dimensional printing has been utilized in various aspects of medicine beyond bioprinting, including custom prosthetics and implants, surgical planning and training, and personalized pharmaceuticals [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

AFM Analysis of a Three-Point Flexure Tested, 3D Printing Definitive Restoration Material for Dentistry

Sandmair

Kleber

Ströbele

et al. 2023

JFB

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Background: Three-dimensional printing is a rapidly developing technology across all industries. In medicine recent developments include 3D bioprinting, personalized medication and custom prosthetics and implants. To ensure safety and long-term usability in a clinical setting, it is essential to understand material specific properties. This study aims to analyze possible surface changes of a commercially available and approved DLP 3D printed definitive restoration material for dentistry after three-point flexure testing. Furthermore, this study explores whether Atomic Force Microscopy (AFM) is a feasible method for examination of 3D printed dental materials in general. This is a pilot study, as there are currently no studies that analyze 3D printed dental materials using an AFM. Methods: The present study consisted of a pretest followed by the main test. The resulting break force of the preliminary test was used to determine the force used in the main test. The main test consisted of atomic force microscopy (AFM) surface analysis of the test specimen followed by a three-point flexure procedure. After bending, the same specimen was analyzed with the AFM again, to observe possible surface changes. Results: The mean root mean square (RMS) roughness of the segments with the most stress was 20.27 nm (±5.16) before bending, while it was 26.48 nm (±6.67) afterward. The corresponding mean roughness (Ra) values were 16.05 nm (±4.25) and 21.19 nm (±5.71) Conclusions: Under three-point flexure testing, the surface roughness increased significantly. The p-value for RMS roughness was p = 0.003, while it was p = 0.006 for Ra. Furthermore, this study showed that AFM surface analysis is a suitable procedure to investigate surface changes in 3D printed dental materials.

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Section: Introductionmentioning

confidence: 99%

AFM Analysis of a Three-Point Flexure Tested, 3D Printing Definitive Restoration Material for Dentistry

Sandmair

Kleber

Ströbele

et al. 2023

JFB

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“…[89] Despite not being yet particularly popular in the field, the 3Dbioprinting of cholangiocytes derived from iPSCs, hepatocytes progenitor cells, or even from embryonic stem cells, is documented in the very recent literature, especially for bile ducts engineering applications. [90][91][92]…”

Section: Cells For Liver Bioinksmentioning

confidence: 99%

Toward 3D‐Bioprinted Models of the Liver to Boost Drug Development

Guagliano

Volpini

Briatico‐Vangosa

et al. 2022

Macromolecular Bioscience

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The main problems in drug development are connected to enormous costs related to the paltry success rate. The current situation empowered the development of high-throughput and reliable instruments, in addition to the current golden standards, able to predict the failures in the early preclinical phase. Being hepatotoxicity responsible for the failure of 30% of clinical trials, and the 21% of withdrawal of marketed drugs, the development of complex in vitro models (CIVMs) of liver is currently one of the hottest topics in the field. Among the different fabrication techniques, 3D-bioprinting is emerging as a powerful ally for their production, allowing the manufacture of three-dimensional constructs characterized by computer-controlled and customized geometry, and inter-batches reproducibility. Thanks to these, it is possible to rapidly produce tailored cell-laden constructs, to be cultured within static and dynamic systems, thus reaching a further degree of personalization when designing in vitro models. This review highlights and prioritizes the most recent advances related to the development of CIVMs of the hepatic environment to be specifically applied to pharmaceutical research, with a special focus on 3D-bioprinting, since the liver is primarily involved in the metabolism of drugs.

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“…1). Many techniques can be applied to create the scaffold, such as casting [2], electrospinning [3] or bioprinting [4]. In addition, the self-assembly technique is a reconstruction method which does not require any exogenous biomaterials [5].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Elia¹,

Brownell²,

Chabaud³

et al. 2022

Preprint

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The gastrointestinal and genitourinary tracts share several similarities. Primarily, these tissues are composed of hollow structures lined by an epithelium through which materials need to flow with the help of peristalsis brought by muscle contraction. In the case of the gastrointestinal tract, solid or liquid food must circulate to be digested and absorbed and the waste products eliminated. In the case of the urinary tract, the urine produced by the kidneys must flow to the bladder, where it is stored until its elimination from the body. Finally, in the case of the vagina, it must allow the evacuation of blood during menstruation, accommodate the male sexual organ during coitus, and is the natural way to birth a child. The present review describes the anatomy, pathologies and treatments of such organs, emphasizing tissue engineering strategies.

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3D Bioprinting of Human Hollow Organs

Cited by 29 publications

References 98 publications

AFM Analysis of a Three-Point Flexure Tested, 3D Printing Definitive Restoration Material for Dentistry

AFM Analysis of a Three-Point Flexure Tested, 3D Printing Definitive Restoration Material for Dentistry

Toward 3D‐Bioprinted Models of the Liver to Boost Drug Development

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

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