3D Nanoporous Anodic Alumina Structures for Sustained Drug Release

Porta-i-Batalla, Maria; Xifré-Pérez, Elisabet; Eckstein, Chris; Ferré‐Borrull, Josep; Marsal, Lluís F.

doi:10.3390/nano7080227

Cited by 25 publications

(31 citation statements)

References 39 publications

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“…. ) and template synthesis methods [10][11][12][13][14][15][16]. Moreover, the optical characteristics of NPASs such as light transmittance, absorbance, or reflectivity can be tools of interest for selective chemical and biochemical applications [9].…”

Section: Introductionmentioning

confidence: 99%

Influence of ALD Coating Layers on the Optical Properties of Nanoporous Alumina-Based Structures

et al. 2019

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Optical changes associated with the surface coating of different metal oxides and nanolayers by the ALD technique of a nanoporous alumina structure (NPAS) obtained by the two-step anodization method were analyzed. The NPASs were coated with: (i) a single layer (SiO2 or TiO2), and (ii) a double layer of SiO2 plus Al2O3 or aluminum doped ZnO (AZO) to estimate the effect of surface layer coverage material, geometrical parameters (pore-size/porosity), and number of layers on light transmission/reflection. Chemical surface characterization of the different NPASs was carried out by analyzing XPS spectra, which allowed us to obtain an estimation of the coating layer homogeneity. Transmittance and spectroscopic ellipsometry measurements were analyzed in order to detect changes in characteristic optical parameters such as band gap, refractive index, and extinction coefficients associated with the material and the characteristics of the single or double coating layers.

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Section: Introductionmentioning

confidence: 99%

Influence of ALD Coating Layers on the Optical Properties of Nanoporous Alumina-Based Structures

et al. 2019

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“…Porous anodic alumina (PAA) can be fabricated on the surface of other materials through anodization process [ 404 , 405 ]. It can be considered a good nanocontainer to load active agents such as drugs or biomolecules [ 406 ]. Evaporation induced self-assembly derived mesoporous aluminum oxide was used for the delivery of poor-water soluble compound Telmisartan (anti-blood pressure drug) with 45% loading efficiency [ 407 ].…”

Section: Nanobiomaterialsmentioning

confidence: 99%

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

et al. 2020

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One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering.

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“…One of the easiest approaches developed over the years is to control drug delivery by modifying the pore dimensions and fabricating different types of nanostructures based on NAA. [37,70] In 2003, Gong et al [95] fabricated mechanically robust tubular NAA membranes of different pore sizes (25-55 nm) using aluminum microtubes as substrate and applying the two-step anodization process in 0.2 m oxalic acid. To conduct diffusion experiments, these tubular membranes were transformed into filtration capsules loaded with two different types of molecules (used to model the elution dynamics) such as fluorescein (small size) and fluorescein isothiocyanate (FITC)-dextran with different molecular weights to study the drug release profiles as a function of pore size.…”

Section: Structural and Surface Modificationsmentioning

confidence: 99%

Nanoporous Anodic Alumina Platforms for Drug Delivery Applications: Recent Advances and Perspective

Kapruwan

Ferré‐Borrull

Marsal

2020

Adv Materials Inter

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dosages to maintain drug level in the body and there is usually a rapid release of the drug directly into the blood circulation within a short time before reaching the desirable site, which might possess a risk of damaging healthy organs. [3] The main problem with these types of delivery vehicles includes poor patient compliance, lack of selectivity, unavoidable drug solubility, and biodistribution along with unfavorable elution kinetics. [4] With recent advances in nanofabrication technologies, drug delivery systems have achieved a significant progress in terms of patient safety, bioavailability, and achieving required therapeutic efficiency. [5,6] Two new branches, i.e., localized drug delivery systems (LDDSs) and targeted drug delivery systems (TDDSs) have emerged to efficiently deliver a drug inside the body using many nano-based drug carriers. These carriers include nanoparticles, liposomes, dendrimers, micelles, nanospheres, nanotubes, graphene. [7-11] Both of these concepts have already been executed in clinical practices performing excellently in terms of cost-effectiveness, less painful technologies, controlled and reliable drug release profile. [12] Amidst different categories of nanomaterials developed for drug release, inorganic nanoporous structures are the center of attraction for most of the researchers today due to its ease of fabrication, cost-effectiveness, and ability to tune structural parameters precisely. [13] In recent years, nanoporous anodic alumina (NAA), porous silicon (pSi), and titania were thoroughly investigated among all nanoporous materials specifically for developing new drug-releasing strategies due to their excellent physiochemical properties and biocompatible properties. [14-16] Among all the materials mentioned above, NAA remains one of the best choices due to its excellent chemical inertness, biocompatibility, enhanced mechanical strength, tunable chemistry, and controlled pore dimensions and volumes for loading and releasing drugs in a controlled manner. [14,17-20] In addition to its biomedical importance, NAA is also being utilized in optical biosensing, energy production, and catalytic applications. [13,21-25] This review compiles the most recent advances in NAA platforms for drug delivery applications with a short introduction for efficient drug delivery strategies developed over the years. To start with, the fundamental fabrication process, their properties, and biocompatibility of NAA are briefly introduced. The main intention is to summarize the different nanostructures based on NAA currently being developed for drug delivery applications, their advantages, and limitations. Furthermore, For several decades, nanoporous anodic alumina (NAA) has been prepared through inexpensive electrochemical anodization of aluminum to prepare diversified periodically ordered nanostructures. It acts as an excellent drug reservoir due to its excellent physical and chemical properties hence minimizing the drug loss and increasing bioavailability to the target site. A rapid increase in ex...

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3D Nanoporous Anodic Alumina Structures for Sustained Drug Release

Cited by 25 publications

References 39 publications

Influence of ALD Coating Layers on the Optical Properties of Nanoporous Alumina-Based Structures

Influence of ALD Coating Layers on the Optical Properties of Nanoporous Alumina-Based Structures

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

Nanoporous Anodic Alumina Platforms for Drug Delivery Applications: Recent Advances and Perspective

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