3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence

Dang, Wentao; Chen, Wei-Chih; Ju, Enguo; Xu, Yanteng; Li, Kai; Wang, Haixia; Wang, Kun; Lv, Shixian; Shao, Dan; Tao, Yu; Li, Mingqiang

doi:10.1186/s12951-022-01454-1

Cited by 40 publications

(17 citation statements)

References 76 publications

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“…Biological scaffolds can not only mimic the chemical composition and layered structure of bone so that their physical and chemical properties are similar to those of human bone, but they can also transport cells, nutrients, oxygen and growth factors to promote tissue regeneration. 36 , 37 Besides, the transporting of medications or the loading of particular metal ions and nanoparticles can provide biological scaffolds the power to inhibit or even kill tumor cells, which is a significant step forward for the application of biological scaffolds in bone tumors. 38 Due to the various site and shape of bone defects, however, biological scaffolds are frequently unable to suit the needs of specific sites and shapes.…”

Section: Destruction Of Bone Structure By Bone Tumorsmentioning

confidence: 99%

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

Ma¹,

Zhang²,

Sun³

et al. 2023

IJN

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Bone tumors, including primary bone tumors, invasive bone tumors, metastatic bone tumors, and others, are one of the most clinical difficulties in orthopedics. Once these tumors have grown and developed in the bone system, they will interact with osteocytes and other environmental cells in the bone system’s microenvironment, leading to the eventual damage of the bone’s physical structure. Surgical procedures for bone tumors may result in permanent defects. The dual-efficacy of tissue regeneration and tumor treatment has made biomaterial scaffolds frequently used in treating bone tumors. 3D printing technology, also known as additive manufacturing or rapid printing prototype, is the transformation of 3D computer models into physical models through deposition, curing, and material fusion of successive layers. Adjustable shape, porosity/pore size, and other mechanical properties are an advantage of 3D-printed objects, unlike natural and synthetic material with fixed qualities. Researchers have demonstrated the significant role of diverse 3D-printed biological scaffolds in the treatment for bone tumors and the regeneration of bone tissue, and that they enhanced various performance of the products. Based on the characteristics of bone tumors, this review synthesized the findings of current researchers on the application of various 3D-printed biological scaffolds including bioceramic scaffold, metal alloy scaffold and nano-scaffold, in bone tumors and discussed the advantages, disadvantages, and future application prospects of various types of 3D-printed biological scaffolds. Finally, the future development trend of 3D-printed biological scaffolds in bone tumor is summarized, providing a theoretical foundation and a larger outlook for the use of biological scaffolds in the treatment of patients with bone tumors.

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Section: Destruction Of Bone Structure By Bone Tumorsmentioning

confidence: 99%

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

Ma¹,

Zhang²,

Sun³

et al. 2023

IJN

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“…They should provide more features than a conventional hydrogel scaffold, e.g., the PTT effect [ 154 ]. One such hydrogel-based therapy is gelatin (Gel), sodium alginate (Alg) hydrogel system loaded with CuO nanoparticles obtained by Dang et al [ 155 ]. This approach combined the photothermal effect and provided biochemical cues resulting in tumor recurrence.…”

Section: 3d Printed Scaffolds and Hydrogels For Anticancer Treatmentsmentioning

confidence: 99%

A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies

Zaszczyńska

Niemczyk-Soczynska

2022

Polymers

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Anticancer therapies and regenerative medicine are being developed to destroy tumor cells, as well as remodel, replace, and support injured organs and tissues. Nowadays, a suitable three-dimensional structure of the scaffold and the type of cells used are crucial for creating bio-inspired organs and tissues. The materials used in medicine are made of non-degradable and degradable biomaterials and can serve as drug carriers. Developing flexible and properly targeted drug carrier systems is crucial for tissue engineering, regenerative medicine, and novel cancer treatment strategies. This review is focused on presenting innovative biomaterials, i.e., electrospun nanofibers, 3D-printed scaffolds, and hydrogels as a novel approach for anticancer treatments which are still under development and awaiting thorough optimization.

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“…26 However, one obvious shortcoming of the unmodified Pluronic F127 hydrogel is its low mechanical strength and stability in physiological conditions. 27,28 Combining Pluronic F127 with other polymer materials such as sodium alginate (SA) via chemical or physical modification is a feasible method to overcome this shortcoming. SA is a polysaccharide with excellent biocompatibility and has been applied to biomedical domains extensively, such as loading drugs and packaging cells.…”

Section: Introductionmentioning

confidence: 99%

“…Its micelles can generate high-viscosity three-dimensional (3D) network gels with increased temperature and concentration . However, one obvious shortcoming of the unmodified Pluronic F127 hydrogel is its low mechanical strength and stability in physiological conditions. , Combining Pluronic F127 with other polymer materials such as sodium alginate (SA) via chemical or physical modification is a feasible method to overcome this shortcoming. SA is a polysaccharide with excellent biocompatibility and has been applied to biomedical domains extensively, such as loading drugs and packaging cells. ,, Additionally, SA can coordinate with common metal ions such as Ca(II), Ba(II), and Cu(II) to form gels.…”

Section: Introductionmentioning

confidence: 99%

Implantable 3D Printed Hydrogel Scaffolds Loading Copper-Doxorubicin Complexes for Postoperative Chemo/Chemodynamic Therapy

Dang

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Biomaterial-based implants hold great potential for postoperative cancer treatment due to the enhanced drug dosage at the disease site and decreased systemic toxicity. However, the elaborate design of implants to avoid complicated chemical modification and burst release remains challenging. Herein, we report a three-dimensional (3D) printed hydrogel scaffold to enable sustained release of drugs for postoperative synergistic cancer therapy. The hydrogel scaffold is composed of Pluronic F127 and sodium alginate (SA) as well as doxorubicin (DOX) and copper ions (F127-SA/Cu-DOX hydrogel scaffold). Benefiting from the coordination of Cu(II) with both SA and DOX, burst release of DOX can be overcome, and prolonged release time can be achieved. The therapeutic efficiency can be adjusted by altering the amount of DOX and Cu(II) in the scaffolds. Moreover, apoptosis and ferroptosis of cancer cells can be induced through the combination of chemotherapy and chemodynamic therapy. In addition, DOX supplies excess hydrogen peroxide to enhance the efficiency of Cu-based chemodynamic therapy. When implanted in the resection site, hydrogel scaffolds effectively inhibit tumor growth. Overall, this study may offer a new strategy for fabricating local implants with synergistic therapeutic performance for preventing postoperative cancer recurrence.

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3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence

Cited by 40 publications

References 76 publications

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies

Implantable 3D Printed Hydrogel Scaffolds Loading Copper-Doxorubicin Complexes for Postoperative Chemo/Chemodynamic Therapy

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