3D Printing in Spine Surgery

Burleson, John; DiPaola, Christian P.

doi:10.1016/b978-0-323-58118-9.00010-5

Cited by 10 publications

(7 citation statements)

References 20 publications

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“…3D printing employs 3D images of the bone trauma anatomy, usually acquired from computed tomography (CT) scans, using a calculating software, to fabricate a bone graft substitutes (BGS) structure that matches to a bony defect (Burleson and DiPaola 2019). The personalized bone graft substitute form is fabricated using a 3D printer to control the BGS mechanical features and substantial parameters.…”

Section: Biomaterial-based 3d Cell-printing Substitutesmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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Nowadays, bone diseases and defects as a result of trauma, cancers, infections and degenerative and inflammatory conditions are increasing. Consequently, bone repair and replacement have been developed with improvement of orthopedic technologies and biomaterials of superior properties. This review paper is intended to sum up and discuss the most relevant studies performed in the field of bone biology and bone regeneration approaches. Therefore, the bone tissue regeneration was investigated by synthetic substitutes, scaffolds incorporating active molecules, nanomedicine, cell-based products, biomimetic fibrous and nonfibrous substitutes, biomaterial-based three-dimensional (3D) cell-printing substitutes, bioactive porous polymer/inorganic composites, magnetic field and nano-scaffolds with stem cells and bone-biomaterials interface studies.

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Section: Biomaterial-based 3d Cell-printing Substitutesmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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“…Various graft materials have been used to treat bone defects, but nowadays all the selective materials have their advantages and drawbacks. Consequently, bone repair and replacement have been developed with advanced improvements of orthopedic technologies and biomaterials of superior properties [4].…”

Section: Introductionmentioning

confidence: 99%

Potential Bone Regenerative Effects of DFDBA, Simvastatin and Platelet Rich Fibrin, Radiographically and Histologically of Intra-Bony Periodontal Defects in White New Zealand Rabbits

El-dien

Fathy

El-Din

2021

Open Access Maced J Med Sci

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AIM: This study aimed to evaluate and to compare the regenerative power of simvastatin, Demineralized Freeze-Dried Bone Allograft (DFDBA) allograft, platelets rich Fibrin (PRF), and a combination of these materials radiographically and histologically in the intra-bony periodontal defects in white New Zealand rabbits. MATERIALS AND METHODS: This study was conducted on 54 defects in 27 adult male rabbits (n = 27) which were divided into three groups according to the follow-up preplanned scheduled for 1, 2, and 3 weeks. The selected materials were induced as following: A=DFDBA, B=Simvastatin, C= PRF, D=A+C, E=B+C, and F=negative (control group). The intra-bony periodontal defects were induced as the form of one osseous wall defect of 10 mm height, 4 mm depth between the first and the second molars. Then, samples were prepared for histological evaluation. Radiographic assessment was done using computed tomography radiography which was carried at different time intervals as the following baseline, 1, 2, and 3 weeks later. Statistical analysis was performed using ANOVA. RESULTS: After evaluating the results, macroanatomy, radiographically, and histologically, it is thus confirmed that DFDBA allograft combined with PRF create the best bone regenerative results, followed by DFDBA, Simvastatin, simvastatin+ PRF, control group, and finally PRF. CONCLUSION: All of the materials examined in this study showed different percentage in terms of bone density and bone regenerative effects. However, the best results for bone density of the DFDBA + PRF group were recorded after 3 weeks. Thus, the study concludes that a combination of DFDBA + PRF reflects the best properties of both materials in terms of bone density results of the defect. Such results are particularly significant for the selection of bone regeneration materials, and generally, for periodontal regeneration.

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“…By visualizing imaging data in a physical form, they were able to plan and rehearse surgery, navigate smoothly intraoperatively and better inform patients about surgical procedures [ 11 ]. Within the last 5 years, 3DP in spine surgery has extended beyond preoperative surgical planning to the creation of patient-specific surgical instruments and the printing of omic implants [ 5 ]. The first omic implants were led by Dr. Liu Zhongjun in 2014.…”

Section: History Of 3dp In Medicine/surgerymentioning

confidence: 99%

Implications of 3-Dimensional Printed Spinal Implants on the Outcomes in Spine Surgery

Newhouse

Cathel

Sarhadi

et al. 2021

J Korean Neurosurg Soc

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Three-dimensional printing (3DP) applications possess substantial versatility within surgical applications, such as complex reconstructive surgeries and for the use of surgical resection guides. The capability of constructing an implant from a series of radiographic images to provide personalized anatomical fit is what makes 3D printed implants most appealing to surgeons. Our objective is to describe the process of integration of 3DP implants into the operating room for spinal surgery, summarize the outcomes of using 3DP implants in spinal surgery, and discuss the limitations and safety concerns during pre-operative consideration. 3DP allows for customized, light weight, and geometrically complex functional implants in spinal surgery in cases of decompression, tumor, and fusion. However, there are limitations such as the cost of the technology which is prohibitive to many hospitals. The novelty of this approach implies that the quantity of longitudinal studies is limited and our understanding of how the human body responds long term to these implants is still unclear. Although it has given surgeons the ability to improve outcomes, surgical strategies, and patient recovery, there is a need for prospective studies to follow the safety and efficacy of the usage of 3D printed implants in spine surgery.

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3D Printing in Spine Surgery

Cited by 10 publications

References 20 publications

Bone tissue regeneration: biology, strategies and interface studies

Bone tissue regeneration: biology, strategies and interface studies

Potential Bone Regenerative Effects of DFDBA, Simvastatin and Platelet Rich Fibrin, Radiographically and Histologically of Intra-Bony Periodontal Defects in White New Zealand Rabbits

Implications of 3-Dimensional Printed Spinal Implants on the Outcomes in Spine Surgery

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