3D Printing of dynamic tissue scaffold by combining self-healing hydrogel and self-healing ferrogel

Choi, Yeonsik; Kim, Choonggu; Kim, Hyun Seung; Moon, Chiung; Lee, Kuen Yong

doi:10.1016/j.colsurfb.2021.112108

Cited by 32 publications

(19 citation statements)

References 38 publications

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“…Furthermore, it has been demonstrated that self-healing printable gels can show macroscopic and reversible change in dimensions in the presence of a magnetic field and thus may be potentially useful in 4D printing [ 61 ]. A similar phenomenon was observed in dynamically cross-linked self-healing ferrogel containing SPIONs [ 62 ]. Moreover, the presence of iron particles enhanced cell proliferation [ 61 ].…”

Section: Introductionsupporting

confidence: 76%

Formulation of Magneto-Responsive Hydrogels from Dually Cross-Linked Polysaccharides: Synthesis, Tuning and Evaluation of Rheological Properties

Vítková

Musilová

Achbergerová

et al. 2022

IJMS

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Smart hydrogels based on natural polymers present an opportunity to fabricate responsive scaffolds that provide an immediate and reversible reaction to a given stimulus. Modulation of mechanical characteristics is especially interesting in myocyte cultivation, and can be achieved by magnetically controlled stiffening. Here, hyaluronan hydrogels with carbonyl iron particles as a magnetic filler are prepared in a low-toxicity process. Desired mechanical behaviour is achieved using a combination of two cross-linking routes—dynamic Schiff base linkages and ionic cross-linking. We found that gelation time is greatly affected by polymer chain conformation. This factor can surpass the influence of the number of reactive sites, shortening gelation from 5 h to 20 min. Ionic cross-linking efficiency increased with the number of carboxyl groups and led to the storage modulus reaching 103 Pa compared to 101 Pa–102 Pa for gels cross-linked with only Schiff bases. Furthermore, the ability of magnetic particles to induce significant stiffening of the hydrogel through the magnetorheological effect is confirmed, as a 103-times higher storage modulus is achieved in an external magnetic field of 842 kA·m−1. Finally, cytotoxicity testing confirms the ability to produce hydrogels that provide over 75% relative cell viability. Therefore, dual cross-linked hyaluronan-based magneto-responsive hydrogels present a potential material for on-demand mechanically tunable scaffolds usable in myocyte cultivation.

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Section: Introductionsupporting

confidence: 76%

Formulation of Magneto-Responsive Hydrogels from Dually Cross-Linked Polysaccharides: Synthesis, Tuning and Evaluation of Rheological Properties

Vítková

Musilová

Achbergerová

et al. 2022

IJMS

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“…The self-repairing performance of these structures is characterized by the healing efficiency and the number of successful healing cycles that follow each other [38]. DIW is considered the most common method for the manufacture of self-healing smart structures [39].…”

Section: Polymersmentioning

confidence: 99%

Active Materials for 3D Printing in Small Animals: Current Modalities and Future Directions for Orthopedic Applications

Memarian

Pishavar

Zanotti

et al. 2022

IJMS

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The successful clinical application of bone tissue engineering requires customized implants based on the receiver’s bone anatomy and defect characteristics. Three-dimensional (3D) printing in small animal orthopedics has recently emerged as a valuable approach in fabricating individualized implants for receiver-specific needs. In veterinary medicine, because of the wide range of dimensions and anatomical variances, receiver-specific diagnosis and therapy are even more critical. The ability to generate 3D anatomical models and customize orthopedic instruments, implants, and scaffolds are advantages of 3D printing in small animal orthopedics. Furthermore, this technology provides veterinary medicine with a powerful tool that improves performance, precision, and cost-effectiveness. Nonetheless, the individualized 3D-printed implants have benefited several complex orthopedic procedures in small animals, including joint replacement surgeries, critical size bone defects, tibial tuberosity advancement, patellar groove replacement, limb-sparing surgeries, and other complex orthopedic procedures. The main purpose of this review is to discuss the application of 3D printing in small animal orthopedics based on already published papers as well as the techniques and materials used to fabricate 3D-printed objects. Finally, the advantages, current limitations, and future directions of 3D printing in small animal orthopedics have been addressed.

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“…Autonomous healing does not require any human intervention and relies either on an embedded healing agent that is released autonomously upon mechanical damage to the reservoir it is stored in or on the intrinsic self-healing potential of polymeric matrices involving dynamic covalent bonds or noncovalent interactions that can reform at the application temperature. Dynamic covalent chemistries include Diels-Alder (DA) reactions, disulfide, imine and boron-based bond exchange [35,[43][44][45][46]. Noncovalent chemistries refer to hydrogen bonds, ionic interactions, metal-ligand bonding, electrostatic interactions and π-π staking [30,32,[47][48][49][50].…”

Section: State-of-the-art Fabrication Methods Of Magnetic Self-healin...mentioning

confidence: 99%

Magnetic Self-Healing Composites: Synthesis and Applications

et al. 2022

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Magnetic composites and self-healing materials have been drawing much attention in their respective fields of application. Magnetic fillers enable changes in the material properties of objects, in the shapes and structures of objects, and ultimately in the motion and actuation of objects in response to the application of an external field. Self-healing materials possess the ability to repair incurred damage and consequently recover the functional properties during healing. The combination of these two unique features results in important advances in both fields. First, the self-healing ability enables the recovery of the magnetic properties of magnetic composites and structures to extend their service lifetimes in applications such as robotics and biomedicine. Second, magnetic (nano)particles offer many opportunities to improve the healing performance of the resulting self-healing magnetic composites. Magnetic fillers are used for the remote activation of thermal healing through inductive heating and for the closure of large damage by applying an alternating or constant external magnetic field, respectively. Furthermore, hard magnetic particles can be used to permanently magnetize self-healing composites to autonomously re-join severed parts. This paper reviews the synthesis, processing and manufacturing of magnetic self-healing composites for applications in health, robotic actuation, flexible electronics, and many more.

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3D Printing of dynamic tissue scaffold by combining self-healing hydrogel and self-healing ferrogel

Cited by 32 publications

References 38 publications

Formulation of Magneto-Responsive Hydrogels from Dually Cross-Linked Polysaccharides: Synthesis, Tuning and Evaluation of Rheological Properties

Formulation of Magneto-Responsive Hydrogels from Dually Cross-Linked Polysaccharides: Synthesis, Tuning and Evaluation of Rheological Properties

Active Materials for 3D Printing in Small Animals: Current Modalities and Future Directions for Orthopedic Applications

Magnetic Self-Healing Composites: Synthesis and Applications

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