4.4′‐Diamino‐benzophenon und andere schwefelfreie Verbindungen mit Sulfonamidwirkung

Kühn, Richard; Möller, Ernst Friedrich; Wendt, G.; Beinert, Helmuth

doi:10.1002/cber.19420750614

Cited by 30 publications

(11 citation statements)

References 10 publications

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“…From this it would appear that the NH2E 7 nucleus may be basic for true SA-like activity after all (84). Kuhn et al (133), however, observed PABA antagonism of 4,4'diamino-benzophenone, 4,4'-diamino-diphenylsulfone, phosphanilic acid and carbopyridin; this indicates that, using PABA reversal as a criterion, the sulfur is not indispensable for true SA-like action.…”

Section: 34mentioning

confidence: 95%

The Mode of Action of Sulfonamides *

Henry¹

1943

Bacteriological Reviews

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Assumptions that the action of sulfonamides is due to their transformation into * The present review is a critical integration of the material believed to be essential to an understanding of the mode of action of the sulfonamides. In order to bring the treatment of the subject within the scope of a review of this character many supporting references and topics have necessarily been excluded. A much more inclusive annotated bibliographic review will be published in the new series of the Josiah Macy, Jr. Foundation.

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Section: 34mentioning

confidence: 95%

The Mode of Action of Sulfonamides *

Henry¹

1943

Bacteriological Reviews

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“…Several derivatives could, to some extent, replace PABA, while p-aminobenzamide was either a growth factor or an inhibitor depending on the concentration. The corresponding thioamide was a growth inhibitor, but Kuhn et al (207) concluded that the thioamide competed with'the organisms for iron, since its bacteriostatic effect could be reversed by iron salts but not by PABA. The corresponding thioamide was a growth inhibitor, but Kuhn et al (207) concluded that the thioamide competed with'the organisms for iron, since its bacteriostatic effect could be reversed by iron salts but not by PABA.…”

Section: Other Paba Antagonistsmentioning

confidence: 99%

“…However, the activity dropped off rapidly with time, and Kuhn et al(207) suggested that a "self-inhibition" caused by the formation of PABA might occur. I1 and IV) produces a thirtyfold increase in effectiveness.…”

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confidence: 99%

Metabolite Antagonists.

Roblin¹

1946

Chem. Rev.

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“…The antimicrobial activity of PA, as that of the sulfonamides, has been reported to be antagonized by pABA in intact cells (4)(5)(6). The antimicrobial spectrum of PA resembled that of the sulfonamide sulfamethoxazole, but PA had significantly greater activity against Pseudomonas aeruginosa (6).…”

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confidence: 99%

Phosphanilic acid inhibits dihydropteroate synthase

Eagon

McManus

1989

Antimicrob Agents Chemother

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Intact cells of Pseudomonas aeruginosa were more susceptible to phosphanilic acid (PA) than cells of Escherichia coli. In cell extracts, the dihydropteroate synthases of P. aeruginosa and E. coli were about equally susceptible to inhibition by PA. These results suggest that cells of P. aeruginosa are more permeable to PA than cells of E. coli. Although a weak inhibitor, PA acted on dihydropteroate synthase in the same manner as the sulfonamides with which PA is structurally related. Inhibition of E. coli by PA in a basal salts-glucose medium was prevented by p-aminobenzoic acid (pABA). However, pABA did not protect P. aeruginosa from PA under these conditions, possibly because pABA itself exhibited an inhibitory effect. PA also appeared to have a second mode of action. The mechanism was not elucidated.

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4.4′‐Diamino‐benzophenon und andere schwefelfreie Verbindungen mit Sulfonamidwirkung

Cited by 30 publications

References 10 publications

The Mode of Action of Sulfonamides *

The Mode of Action of Sulfonamides *

Metabolite Antagonists.

Phosphanilic acid inhibits dihydropteroate synthase

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