4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine

Abstract

The pyrazolo­[3,4-d]pyrimidine ring system of the title compound, C12H10N4S, is essentially planar [maximum deviation = 0.025 (1) Å for the C atom bearing the S atom] and almost perpendicular to the phenyl ring [dihedral angle = 71.42 (6)°]. In the crystal, mol­ecules are linked via pairs of N—H⋯N hydrogen bonds, forming inversion dimers.

1-Methyl-3-(2-methylphenyl)-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine

“…In recent years, researchers have reported the use of purine derivatives of pyrazolo [3,4-d]pyrimidine as kinase inhibitors (Diner et al, 2012), antiviral agents (Bektemirov et al, 2010) and antitubercular agents (Trivedi et al, 2012). The present paper is a continuation of our research work devoted to the development of pyrazolo [3,4-d]pyrimidine derivatives with potential pharmacological activities (El Fal et al, 2013).…”

The crystal structure of 1,5-dibenzyl-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-thione

“…Data collection: APEX2 (Bruker, 2009); cell refinement: SAINT-Plus (Bruker, 2009); data reduction: SAINT-Plus; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012); software used to prepare material for publication: PLATON (Spek, 2009) and publCIF (Westrip, 2010 (Orlikova et al, 2014;Yuan et al, 2013;Rashad et al, 2011). The present paper is a continuation of our research work devoted to the development of pyrazolo[3,4-d] pyrimidine derivatives with potential pharmacological activities (El Fal et al, 2013;El Fal et al, 2014;Alsubari et al, 2011;Ramli et al, 2012).…”

Crystal structure of 1-methyl-4-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine

“…For similar compounds, see : El Fal et al (2013, 2014a; Ouzidan et al (2011). For pharmacological and biochemical properties of pyrazolo [3,4-d]pyrimidine-4(5H)-thione derivatives, see : Chauhan & Kumar (2013); Venkatesan et al (2014); Rashad et al (2011).…”

“…(Chauhan et al, 2013), antitubercular (Venkatesan et al, 2014) and anticancer (Rashad et al, 2011) agents. During the search for new antibacterial agents synthesis, some 1H-pyrazolo [3,4-d] pyrimidine-4-thiol derivatives were prepared (El Fal et al, 2013, 2014a, 2014bOuzidan et al, 2011). These compounds are currently under investigation for possible biological activity.…”