461 How caregiver’s hospital consultation timing is influenced by the care target II -in case of ASD, ADHD, allergic or other diseases

Abstract

expert) clinical assessment of patient came to Child and Youth protection Center, Zagreb, Croatia, in case of adverse childhood experiences, acording ACEs (Adverse Childhood Experience score) ! 4. From 2015 -2019 in Child and Youth Protection Center Zagreb we prospectively observed 1053 children with ! 4. We were looking for presence of minor neurological dysfunctions (gross motor function, mild dysfunction in posture, reflexes, coordination, fine manipulative ability, fine motor disfunction, dyskinesia and excessive associated movements). For those with ACES !4, and neurodevelopmental delay, EEG was indicated. We also evaluated simptoms of impulsivity, hyperactivity, and an inability to focus.Neglect, physical and emotional abuse and high conflict divorce are the most important adverse experiences resulting in deviations in neurodevelopment.Impulsive behaviour, and other form of ADHD 'like' variants are significantly more frequent (over 50%) in children with history of some kind of abuse or neglect. Over 70% of patients with ACES !4 showed dysrhytmic or other form of nonspecific changes in EEG.In order to understand better the processes of the effects of toxic stress on the developing brain and identify forms of intervention, we have to apply several levels of studyscientific and theoretical, empirical and professional. An integrative paradigm in an approach to neurodevelopmental disorders caused by negative environmental factors provides the conceptual framework for further insight.