471 MGMT Methylation As a Novel Biomarker for the Identification of Stage III Colorectal Cancers At High-Risk of Disease Recurrence Following Curative Surgery

Mori, Yuichi; Nagasaka, Takeshi; Tazawa, Hiroshi; Umeda, Yuzo; Morikawa, Tatsuya; Kubota, Naohiro; Yoshida, Kazuhiro; Takehara, Yuko; Yokomichi, Naosuke; Takehara, Kiyoto; Shigeyasu, Kunitoshi; Nyuya, Akihiro; Shiwaku, Rikiya; Suno, Manabu; Nishida, Naoshi; Fujiwara, Toshiyoshi; Goel, Ajay

doi:10.1016/s0016-5085(13)60315-7

Cited by 2 publications

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“…Even though our study showed low MGMT expression in a low percentage of the metastatic cases, which theoretically could be disappointing, this will not preclude any benefit gained from applying MGMT detection in metastatic CRC cases and the trials using alkylating chemotherapeutics, as TMZ for cases with low expression [33]. Furthermore, Mori showed that patients with methylation and loss of expression of MGMT in tissue are valuable biomarkers for detection of Stage III CRC at high risk of recurrence [34]. It is worth mentioning that our study included four cases (colonic and Stage II) that showed low MGMT expression, one of them showed perineural invasion, and one of the high-risk features.…”

Section: Figure 3: Histogram Showing the Significant Relationship Between Desmoplastic Reaction And Tumor Budding; The Immaturity Of Stromentioning

confidence: 68%

MGMT Immunohistochemical Expression in Colorectal Carcinoma and its Correlation with Tumor Progression

Ahmed

Bayoumi

Abdallah

et al. 2021

Open Access Maced J Med Sci

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Introduction: There is an urgent need to identify predictive features and markers for colorectal carcinoma (CRC) progression and treatment. This study aimed to assess O6-methylguanine DNA methyltransferase (MGMT) expression in CRC and correlate with the clinico-pathological aspects of the tumor, also to evaluate the relationship between different histopathologic parameters and tumor progression. Material and Methods: The study was carried on 70 colectomy using formalin fixed paraffin embedded tumor tissue. Immunohistochemistry was used to detect MGMT expression, and clinico-pathologic aspects as well as Tumor budding, type of desmoplastic reaction, inflammatory lymphocytic milieu, pattern of invasive front and necrosis were assessed Then correlated with MGMT expression and tumor progression, using parametric and nonparametric statistical methods. Results: MGMT Loss of expression was detected in 42.9% of CRC cases. MGMT expression status was significantly correlated with tumor stage and metastatic status (p<0.05), while it was not correlated with other clinic-pathologic features, (p>0.05). Desmoplastic reaction (DR), tumor budding, stromal tumor infiltrating lymphocytes (TIL-S) and necrosis were correlated with tumor stage (p<0.05). DR correlated with tumor budding (p<0.05). Both types of TIL and Crohn’s-like lymphoid reaction (CLR) showed a mutual correlation (p<0.05). Conclusion: MGMT high expression and histopathologic parameters as DR, tumor budding, inflammatory lymphocytic milieu and necrosis could be correlated with CRC progression.

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Section: Figure 3: Histogram Showing the Significant Relationship Between Desmoplastic Reaction And Tumor Budding; The Immaturity Of Stromentioning

confidence: 68%

MGMT Immunohistochemical Expression in Colorectal Carcinoma and its Correlation with Tumor Progression

Ahmed

Bayoumi

Abdallah

et al. 2021

Open Access Maced J Med Sci

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Minichromosome maintenance deficient 6 as a core biomarker for the identification of gynecological pan-carcinoma

Liu

Gao

et al. 2020

mat express

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Cervical, endometrial, and breast cancers are common diseases studied in the field of gynecology. We conducted a series of bioinformatics analyses on these different gynecological cancers. After downloading mRNA microarray data on these gynecological cancers from the TCGA database, we applied a differential analysis. We combined the differential genes obtained from each disease sample and obtained 2,353 public differential genes (P <0.01). Through a weighted gene co-expression network analysis, we obtained five functional disorder modules, and found the essential genes to be LHFP, DNAJC27, GIMAP4, MCM6, and AIM1L. The analysis results showed that dysfunctional genes are associated with ameoidal-type cell migration and DNA replication. We predicted the regulator using cpRNA and a pivot analysis of the transcription factors. Studies have shown that miR-21-5p and miR-300 regulate three modules, MSC regulates m3 and m5, and YBX1 regulates m4 and m5. All are involved in the regulation of m5, and the co-regulated core gene of m5 is MCM6. We believe that MCM6 has a central regulatory role in a disease network and that MCM6 can be considered as a core biomarker for gynecological pan-cancer.

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471 MGMT Methylation As a Novel Biomarker for the Identification of Stage III Colorectal Cancers At High-Risk of Disease Recurrence Following Curative Surgery

Cited by 2 publications

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MGMT Immunohistochemical Expression in Colorectal Carcinoma and its Correlation with Tumor Progression

MGMT Immunohistochemical Expression in Colorectal Carcinoma and its Correlation with Tumor Progression

Minichromosome maintenance deficient 6 as a core biomarker for the identification of gynecological pan-carcinoma

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